血清抗核糖体P蛋白抗体检测对系统性红斑狼疮的诊断价值  

Detection and value of serum antibody to ribosomal P protein in patients with systemic lupus erythematosus

作　　者：王细宏[1] 朱书奇[1] 胡义忠[1] 吴芬[1] 

机构地区：[1]安徽省池州市人民医院,安徽池州247000

出　　处：《安徽医药》2010年第8期916-917,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨抗核糖体P蛋白抗体(ARPA)检测对诊断系统性红斑狼疮(SLE)的诊断价值。方法用线性免疫法(LIA)检测了40例系统性红斑狼疮(SLE),42例干燥综合征(SS)患者,67例类风湿关节炎(RA)患者血清抗核抗体(ANA)谱,同时检测了30例健康体检人员ANA谱作为对照组,应用χ2检验进行统计学分析。结果SLE患者血清中的ARPA阳性率显著高于其他风湿性疾病对照组和正常对照组(P<0.05)。对诊断SLE的敏感性为32.5%,特异性100%。SLE患者血清中ARPA、抗ds-DNA、抗Histone、抗U1-snRNP、ANuA和抗Sm抗体中一项阳性的有31例,阳性率为77.5%。结论ARPA与SLE的临床表现及实验室指标具有相关性;联合检测ARPA、抗dsDNA、抗Histone、抗U1-snRNP、ANuA和抗Sm抗体对SLE的临床诊治具有重要价值。Aim To investigate to the diagnostic value of anti-ribosomal P protein in systemic lupus erythematosus. Methods Line immunoassay method was conducted in 40 patients with systemic lupus erythematosus,42 patients with Sjogren＇s syndrome and 30 healthy control. The relationship between them was analyzed with Chi-square test. Results The positive rate of ARPA in SLE was obviously higher than patients with other diseases and health（P 〈 0.05）. The diagnostic sensitivity of ARPA was 32.5% with specificity of 100%. There were 31 patients with one autoantibody positive in the serum levels of antlnuclear antibody of anti-ribosomal P protein antibody （ARPA）, anti-dsDNA antibody, anti-histone antibody, anti-U1 snRNP antibody, anti-nucleosome antibody （AnuA） and anti-Sm antibody. The positive rate was 77.5%. Conclusion Anti-ribosomal P protein antibody in SLE patients has dependability with clinical features. The combined determination of anti-ribosomal P protein antibody （ARPA）, anti-dsDNA antibody, anti-histone antibody, anti-UlsnRNP antibody, anti-nucleosome antibody （AnuA） and anti-Sm antibody has an important significance in diagnosis and treatment of SLE.

关 键 词：红斑狼疮 自身抗体 抗核糖体P蛋白抗体 线性免疫分析法 

分 类 号：R593.241[医药卫生—内科学]