系统性红斑狼疮合并妊娠35例临床分析  

Pregnancy complicated with systemic lupus erythematosus:clinical analysis of 35 cases

作　　者：吕文杰[1] 

机构地区：[1]安徽医科大学第一附属医院,安徽合肥230022

出　　处：《安徽医药》2010年第8期928-930,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨系统性红斑狼疮合并妊娠的临床特点、孕产期处理及妊娠结局。方法对35例系统性红斑狼疮合并妊娠的临床资料进行回顾性分析。结果孕期SLE病情活动者13例(活动组),非活动者22例(非活动组)。活动组患者子痫前期发生率38.46%,胎儿生长受限发生率69.23%,非活动组发生子痫前期0例,胎儿生长受限发生率13.64%,两组分别比较差异有统计学意义(P均<0.05)。活动组患者胎膜早破、胎儿窘迫、产后出血、早产的发生率及胎儿丢失率均高于非活动组,但差异均无统计学意义(P均>0.05)。结论妊娠期SLE患者易出现产科并发症,加强孕期母婴监护,正确使用肾上腺皮质激素,多数患者能获得良好的结局。Aim To explore the clinical characteristics,the treatment and the outcome of pregnancy complicated with systemic lupus erythematosus （SLE）. Methods The clinical data of 35 pregnant women complicated with SLE were retrospectively investigated. Results The disease was active in 13 cases （the active group） and inactive in 22 cases （the inactive group）. In the active group the rate of pre-eclampsia was 38.46% and the rate of fetal growth restriction （FGR） was 69.23% ,while in the inactive group the rate of pre-eclampsia was 0% and the rate of fetal growth restriction （FGR） was 13.64%. Significant difference was found between the two groups （P 〈 0.05 ）. The rate of premature rupture of membrane, fetal distress, postpartum hemorrhage, premature delivery and pregnant loss in the active group was higher than that in the inactive group, but there was not significant difference between the two groups （P 〉 0.05 ）. Conclusion Pregnancy complications were increased in the patients of pregnancy complicated with SLE. With intensive guardianship for mother and infants, proper use of adrenal cortical hormone, most of the pregnant women with SLE could get well pregnancy outcome.

关 键 词：系统性红斑狼疮 妊娠 妊娠并发症 

分 类 号：R714.2[医药卫生—妇产科学]