细菌溶解产物联合孟鲁司特治疗儿童哮喘的疗效观察  

Therapeutic efficacy of bacterial lysates and montelukast treatment in children with intermittent asthma

作　　者：高原[1] 钱旭波 俞晨艺[3] 宣妙燕[3] 林振浪[3] 

机构地区：[1]金华市中心医院儿科 [2]义乌东方医院 [3]温州医学院附属育英儿童医院

出　　处：《中国临床药理学与治疗学》2010年第5期547-550,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：浙江省义乌市科研计划项目(08-3-05)

摘　　要：目的:探讨细菌溶解产物(泛福舒)联合孟鲁司特口服对间歇发作的支气管哮喘患儿的临床疗效及安全性。方法:173例间歇发作的支气管哮喘患儿随机分为两组:实验组87例,用孟鲁司特咀嚼片口服12个月,前3个月同时服用细菌溶解产物;对照组86例,仅给予孟鲁司特咀嚼片口服12个月。两组均随访12个月,记录两组患儿临床表现、血液淋巴细胞亚群、免疫球蛋白及不良反应情况。结果:173例中有156例(实验组76例,对照组80例)完成随访12个月。与对照组比较,实验组的哮喘发作次数、呼吸道感染次数、发热天数、咳嗽天数与抗生素使用天数均少于对照组,差异均有统计学意义(P<0.05)。治疗后3个月时,实验组CD3+%、CD4+%、CD4+/CD8+比值、血清IgA和唾液sIgA高于对照组,差异均有统计学意义(P<0.01);两组CD8+%、IgG、IgM和IgE差异无统计学意义(P>0.05)。两组不良反应发生率比较差异无统计学意义(校正χ2=0.856,P>0.05)。结论:间歇发作的支气管哮喘患儿联合使用细菌溶解产物和孟鲁司特口服可显著减少哮喘发作次数,疗效明显优于单独使用孟鲁司特,两种药物联合使用无明显不良反应。AIM：To determine the therapeutic efficacy of bacterial lysates （Broncho-Vaxom） plus montelukast treatment in children with bronchial asthma. METHODS：With parental approval,173 children with intermittent asthma were randomized to receive montelukast plus bacterial lysates treatment as experimental group or receive montelukast treatment as a control group. The episodes of respiratory tract infection and asthma exacerbation,T lymphocyte subsets,immunoglobulin and the adverse events were recorded in the following 12 months. RESULTS：A total of 156 patients （76 in the experimental group,80 in the control group） were completed in the study. Compared with control group,The frequencies of asthma exacerbation and respiratory tract infection,duration of fever,cough and antibiotics usage in experimental patients with bronchial asthma were significantly reduced （P〈0.05）,and the levels of CD3^＋%,CD4^＋%,CD4^＋/CD8＋,serum IgA and salivary slgA were obvious increased in the experimental group （P〈0.01）.There were no significant differences in the level of CD8＋%,serum IgM and serum IgG between two groups（P〉0.05）. No serious adverse events was reported in both groups （χ^2=0.939,P〉0.05）. CONCLUSION：The results of this study suggest that treatment with bacterial lysates and montelukast may be effective and safe in children with intermittent asthma.

关 键 词：儿童 哮喘 淋巴细胞亚群 免疫球蛋白 细菌溶解产物 

分 类 号：R562[医药卫生—呼吸系统]