青蒿素及其衍生物药理作用研究有关进展  

Advances on the study of the pharmacological effects of artemisinin and its derivatives

作　　者：李斌[1] 周红[1] 

机构地区：[1]第三军医大学药学院药理学教研室,重庆400038

出　　处：《中国临床药理学与治疗学》2010年第5期572-576,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金(30772628);重庆市自然科学基金计划项目重点项目(CSTC;2009BA5008)

摘　　要：青蒿素属倍半萜内酯化合物,其衍生物主要有双氢青蒿素、青蒿琥酯、蒿甲醚和蒿乙醚,现在临床上主要用于治疗疟疾。随着对青蒿素及其衍生物药理作用的研究不断深入,除抗疟作用外,近年来又相继报道了抗炎、抗细菌脓毒症、抗肿瘤、放射增敏、抗菌增敏、抗组织纤维化等作用。笔者在此对国内外近年发现的青蒿素及其衍生物药理作用研究的最新现状作一综述。Artemisinin is a sesquiterpene lactone compounds,their derivatives include mainly dihydroartemisinin,artesunate,artemether and Artemisia ether. These drugs are now mainly used for clinical treatment of malaria. With the pharmacological action of artemisinin and its derivatives have been further studied,except antimalarial effects,researchers have found their anti-inflammatory,anti-sepsis,antitumor,radiosensitization,antimicrobial sensitivity,anti-fibrosis effects in recent years. Here,we collect and review the most newly pharmacological effects of artemisinin and its derivatives all over the world in past years.

关 键 词：青蒿素 衍生物 药理作用 

分 类 号：R96[医药卫生—药理学]