注射用氨溴索对重症肺炎患者炎症因子的影响  

Impact of Ambroxol on Inflammatory Factor in Patients with Severe Pneumonia

作　　者：叶小玲[1] 尹海燕[1] 邓哲彤[1] 张敏[1] 晋金兰[1] 张锐[1] 江颖仪[1] 冯志顺[1] 

机构地区：[1]暨南大学附属第四医院广州市红十字会医院中心ICU,510220

出　　处：《岭南急诊医学杂志》2010年第3期165-166,共2页Lingnan Journal of Emergency Medicine

基　　金：广东省科技厅科技计划项目基金资助(2008B030301013)

摘　　要：目的:探讨注射用氨溴索对重症肺炎患者炎症反应因子的影响。方法:将入住中心ICU的70例重症肺炎患者随机分成对照组和治疗组各35例,比较两组治疗第2、4天后采用酶联免疫吸附法(ELISA)检测血清中肿瘤坏死因子-α(TNF-α)、(IL-6)及C-反应蛋白(CRP)水平的变化。结果:治疗组TNF-α、CRP水平在治疗第2、4天后较对照组均有明显下降(P<0.05)。结论:注射用氨溴索可明显降低重症肺炎患者血清中炎症因子水平,抑制炎症反应。Objective：To investigate the impact of Ambroxol on inflammatory response in patients with severe pneumonia. Methods： 70 patients with severe pneumonia in the intensive care unit were randomly divided into control group and treatment group, and each group was 35 cases. Comparing serum tumor necrosis factor-α （TNF-α）, intedeukin -6 （IL-6） and C-reactive protein （CRP） levels detected by enzyme-linked immunosorbent assay （ELISA） after treatment for 2 days and 4 days respectively between the two groups. Results： The levels of TNF-α, IL-6 and CRP in treatment group were lower than those in the control group significantly,P〈0.05. Conclusion： Ambroxol can significantly reduce serum levels of inflammatory factors in patients with severe pneumonia and thereby inhibiting the inflammatory reaction.

关 键 词：注射用氨溴索 重症肺炎 C-反应蛋白 肿瘤坏死因子-Α 白介素-6 

分 类 号：R563.1[医药卫生—呼吸系统]