中药白附子炮制前后对小鼠体内抗肿瘤作用的影响  

Comparative study on antitumor activity in vivo of Rhizoma Typhonii before and after processing

作　　者：张振凌[1] 赵丽娜[1] 张红伟[1] 刘博[1] 

机构地区：[1]河南中医学院药学院,郑州450008

出　　处：《中华中医药杂志》2010年第7期1009-1011,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家"十一五"科技支撑计划课题(No.2006BAI09B06)~~

摘　　要：目的:比较白附子(禹白附)加压炮制前后水煎剂和醇提物在动物体内的抗肿瘤作用。方法:采用小鼠移植性肿瘤模型,观察白附子生品、加压制品水煎剂和醇提物对S180肉瘤荷瘤小鼠的抑瘤作用及对S180荷瘤小鼠免疫器官的影响。结果:白附子生品和加压炮制品提取物均有一定的抗肿瘤作用,且生品强于制品;制品提取物有一定的增强小鼠机体免疫功能作用;与对照组比较,白附子生品各剂量组对荷瘤小鼠无生命延长作用、制品醇提物各剂量组对S180腹水瘤荷瘤小鼠有一定生命延长作用。结论:白附子加压法炮制前后水煎剂和醇提物均有一定的抗肿瘤作用和免疫调节作用,临床宜用制白附子。Objective：To compare antitumor activity in vivo of Rhizoma Typhonii before and after processing. Methods：To observe the effect of water decoction and ethanol extract from Rhizoma Typhonii before and after processing on the sarcoma grafts and immune organs of S180 mice by using mice transplant tumor model. Results：The results showed that both of the Rhizoma Typhonii and processed Rhizoma Typhonii had antitumor effect,and the former was stronger than the latter. The extract from processed Rhizoma Typhonii can inhance the immune function of mouse at some extent. Compared with control group,the Rhizoma Typhonii before processing had no effect in prolonging the life of tumor-bearing mouse. But,the ethanol extract from processed Rhizoma Typhonii can prolong the life of S180 mouse. Conclusion：Decoction and ethanol extract from Rhizoma Typhonii and processed Rhizoma Typhonii had antitumor effect. Processed Rhizoma Typhonii can enhance immune function and increase in life span on S180 mice,So processed Rhizoma Typhonii should be used in clinical medicine.

关 键 词：白附子 炮制 抗肿瘤作用 

分 类 号：R283[医药卫生—中药学] R285[医药卫生—中医学]