脂汰清颗粒对实验性动脉粥样硬化兔主动脉内皮细胞的影响  

Effects of Zhitaiqing Granule on aortic endothelial cellsIn rabbit with experimental atherosclerosis

作　　者：叶世龙[1] 刘爱芹[1] 苏宁[2] 张永斌[2] 

机构地区：[1]深圳市宝安区中医院,深圳518133 [2]广州中医药大学,广州510405

出　　处：《中华中医药杂志》2010年第7期1092-1095,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：广东省中医药局项目(No.2009317)~~

摘　　要：目的:探讨脂汰清颗粒对实验性动脉粥样硬化兔主动脉内皮细胞的影响。方法:将新西兰兔随机选取10只作空白对照组,喂普通饲料;其余按高脂饲料配方1饲喂6周,制成高脂血症模型,再随机分为模型组、脂汰清治疗组、辛伐他汀对照组、山楂精降脂片对照组。从第7周开始,正常组喂全价营养饲料,余组改喂高脂饲料配方2。同时,脂汰清组及两对照组分别给相应溶化药物,空白组和模型组给等量生理盐水,灌胃,连续11周后检测总胆固醇(CHO)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白AI(apo AI)、载脂蛋白B(apo B),光学显微镜下观察主动脉弓、胸主动脉和腹主动脉组织内膜的病理变化。结果:脂汰清组可显著降低CHO、LDL-C、ApoB(P<0.05,P<0.01),升高HDL-C(P<0.05),抑制动脉粥样硬化斑块的形成。结论:脂汰清颗粒有较好的调节血脂代谢、抗动脉粥样硬化作用。Objective：To investigate the effects of Zhitaiqing Granule on aortic endothelial cells in rabbit with experimental atherosclerosis. Methods：10 New Zealand rabbits were selected as blank control randomly and fed with normal forage,while the rest rabbits were fed with high-fat forage in formula A. After six weeks,hyperlipidemia models were formed and they were randomly divided into model group,Zhitaiqing treatment group,simvastatin control group and hawthorn tablet control group. From the 7th week,rabbits in treatment and control groups were fed with corresponding drugs while the blank and model groups with the same quantity of normal saline by lavage. After 11 weeks lavage,total cholesterol （CHO）,triglyceride （TG）,high-density lipoprotein cholesterol （HDL-C）,apolipoprotein AI （apo AI）,apolipoprotein B （apo B）.were detected. With the help of optical microscope,the pathological changes of the aortic arch,thoracic aorta and abdominal aortic intima were observed. Results：In Zhitaiqing group,CHO,LDL-C,and ApoB reduced dramatically （P0.05,P0.01）,at the same time,HDL-C increased （P0.05）,which prohibited the formation of atherosclerotic plaque. Conclusion：Zhitaiqing Granule had effects in adjusting the lipid metabolism and anti-atherosclerosis.

关 键 词：脂汰清颗粒 高脂血症 动脉粥样硬化 病理学 

分 类 号：R285.5[医药卫生—中药学]