重症大疱型药疹患者血清胸腺活化调节趋化因子与可溶性FasL的检测  

Detection of the serum levels of thymus and activation-regulated chemokine and soluble FasL in patients with severe bullous drug eruptions

作　　者：于燕华[1] 张美华[1] 

机构地区：[1]南京医科大学第一附属医院皮肤性病科,江苏南京210029

出　　处：《临床皮肤科杂志》2010年第7期426-428,共3页Journal of Clinical Dermatology

摘　　要：目的:检测重症多形红斑(SJS)和中毒性表皮坏死松解症(TEN)型药疹患者血清胸腺活化调节趋化因子(TARC)以及可溶性FasL的表达水平,探讨其在SJS/TEN发病机制中的作用和临床意义。方法:采用酶联免疫吸附试验(ELISA)法对20例重症大疱型药疹患者(15例SJS,5例TEN)进展期和经糖皮质激素等治疗后恢复期血清中TARC和可溶性FasL的水平分别进行测定,以15份正常人血清作为对照。结果:①进展期患者血清中TARC和可溶性FasL水平均高于正常对照组(P<0.05,P<0.01),而恢复期与正常对照组差异无统计学意义(P>0.05,P>0.05);②进展期血清中TARC和可溶性FasL水平均高于恢复期血清中的表达水平(P<0.05,P<0.01),且两者水平呈正相关(r=0.544,P<0.05)。结论:TARC和可溶性FasL在SJS/TEN发病中可能有一定的作用。Objective：To detect the serum levels of thymus and activation-regulated chemokine （TARC） and soluble FasL in patients with severe bullous drug eruptions, including Stevens-Johnson syndrome and toxic epidermal necrolysis, and to study their relationship with the development of SJS/TEN. Methods： Twenty blood samples were collected from patients with SJS/TEN, includ- ing fifteen cases of SJS and five cases of TEN, as well as fifteen from normal human controls. Their serum levels of TARC and soluble FasL were measured by ELISA assay. Results： The serum levels of TARC and soluble FasL in patients with progressive SJS/TEN were significantly increased compared with those in normal controls （P〈0.05 and P〈0.01, respectively） and patients with stable SJS/ TEN （P〈 0.05 and P〈 0.01,respectively）, no significant differences were found between patients with stable SJS/TEN and normal controls（P〉0.05 and P〉0.05 ,respectively）. There was a positive correlation between serum levels of TARC and soluble FasL（r=0.544, P〈 0.05 ）. Conclusions： The results support the pathophysiologcal roles of TARC and soluble FasL in SJS/TEN.

关 键 词：药疹 胸腺活化调节趋化因子 FASL 可溶性 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]