胸腺的增龄化萎缩与免疫重建  

Thymic Involution in Aging and Immune Reconstitution

作　　者：于鸿晶[1] 吴明媛[1] 向砥[1] 俞雁[2] 韩伟[1] 

机构地区：[1]上海交通大学药学院再生组学课题组,上海200240 [2]上海交通大学农业与生物学院上海市兽医生物技术重点实验室,上海200240

出　　处：《中国细胞生物学学报》2010年第3期485-490,共6页Chinese Journal of Cell Biology

基　　金：上海市科学技术委员会(No.075407071;No.09540700600)资助项目~~

摘　　要：随着年龄的增长,胸腺萎缩导致T细胞生成的减少和外周初始T细胞(na(i|¨)ve T cell)输出的减少,增加了临床上许多疾病的发病率与致死率,因此了解胸腺萎缩的机制及其内环境的变化对相关临床疾病的预防和治疗至关重要。目前的研究表明,人们可通过治疗而停止甚至逆转胸腺的萎缩过程。本文将就细胞因子,如白细胞介素7、角质细胞生长因子和性激素,对恢复胸腺功能与重建外周免疫系统的研究进展做一综述。Aging is associated with involution of the thymus, leading to reduction in both T-cell development and emigration of naive T cells to the periphery. Thymic involution leads to increased morbidity and mortality in many clinical settings. Considering of the negative consequences, it is important to understand the mechanisms driving thymic involution and homeostatic processes across the lifespan. There is growing evidence that the involu- tion process of thymus might be therapeutically halted or reversed. We present here factors such as interleukin 7, keratinocyte growth factor and sex steroid ablation could be used for therapeutic thymus restoration and peripheral immune reconstitution.

关 键 词：胸腺 免疫重建 IL-7 SSA KGF 

分 类 号：R392[医药卫生—免疫学]