先天性厚甲症伴多发性皮角1例  

A Case of Pachyonychia Congenita with Multiple Cutaneous Horn

作　　者：贺伟[1] 乌日娜[1] 

机构地区：[1]内蒙古医学院第一附院皮肤科,内蒙古呼和浩特010050

出　　处：《中国皮肤性病学杂志》2010年第7期595-597,共3页The Chinese Journal of Dermatovenereology

摘　　要：患者男,18岁。甲及掌跖部皮损18年。皮损特征表现为:20甲高度增厚、掌跖部严重角化、毛囊角化,尤以肘膝部明显、乳头角化及面部多发性皮角样损害。皮肤活检示:表皮高度角化过度及灶性角化不全,真皮少量炎症细胞浸润。诊断:先天性厚甲症;多发性皮角。A 18-year-old man presented with skin lesions for 18 years. The lesions were characterized by distinctively and excessively thickened 20 nails of all fingers and toes ; palmar and planter hyperkeratosis ; follicular keratosis of skin, especially on the knees and elbows ; nipple keratosis ; multiple cutaneous horn-like lesions on the face. The skin biopsy showed epidermal hperkeratosis, focal parakeratosis and some inflammatory cell in- filtration around vasculars in upper dermal. It was diagnosed as Pachyonychia Congenita with Multiple Cuta- neous Horn, which is a rare congenital disease.

关 键 词：厚甲症 先天性 皮角样损害 基因 

分 类 号：R758.72[医药卫生—皮肤病学与性病学]