髓样分化因子88在尖锐湿疣组织中的表达及意义  

The Expression and Significance of MyD88 in Condyloma Acuminatum

作　　者：史毓杰[1] 熊峰[1] 杨健[1] 杨文林[1] 叶婷[1] 危焕平[1] 

机构地区：[1]广州医学院第二附属医院皮肤科,广东广州510260

出　　处：《中国皮肤性病学杂志》2010年第7期626-628,共3页The Chinese Journal of Dermatovenereology

基　　金：广州医学院博士启动科研基金项目(2008C38)

摘　　要：目的探讨髓样分化因子88(MyD88)在尖锐湿疣(CA)患者皮损中的表达及意义。方法收集CA患者皮损和正常成年人包皮组织各22例,应用免疫组化EnVision二步法检测MyD88蛋白表达在两组标本中的表达,并分析其与CA发病的关系。结果 MyD88在CA患者皮损组的阳性表达率为86.36%,并在表皮全层均有表达,主要定位于基底细胞和棘层细胞的细胞浆和/或细胞核,在正常对照组阳性表达率为54.55%,主要定位于基底细胞;两组相比较,CA患者皮损组MyD88的阳性表达率和表达程度均显著增高,差异有统计学意义(P=0.000);复发组MyD88表达高于初发组,差异也有统计学意义(P=0.005)。结论 MyD88可能在CA免疫发病机制中发挥着重要作用。Objective To investigate the expression and significance of MyD88 in condyloma acuminatum （CA） tissue. Methods The expression of MyD88 was detected by immuohistochemical staining in 22 cases of CA tissues and normal acrobystia tissues. Results MyD88 proteins was positive in 86.36% of CA, but in 54.55% of normal tissue. MyD88-positive cells were observed in the the cytoplasma and cell nucleus of prickle and basal cells superficial layer in CA, whereas positive cells were only seen the basal cell layer in normal tissue. The expression rate and expression degrees of MyD88 in CA were most higher than those in normal acrobystia tissue （P =0.000）. The expression in recurrence cases was higher than primary patients （P =0.005）. Conclusion The expression of MyD88 may play an important role in the occurrence and develop of CA.

关 键 词：尖锐湿疣 MYD88 免疫组化 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]