血清标本10546份非梅毒螺旋体抗原血清学试验假阳性结果分析  

The False Positive Non-treponemal Antigen Serologic Test in 10546 Sera Samples

作　　者：张津萍[1] 王千秋[1] 龚匡隆[1] 尤永燕[1] 沙仲[1] 孙厚华[1] 

机构地区：[1]中国医学科学院北京协和医学院皮肤病医院,江苏南京210042

出　　处：《中国皮肤性病学杂志》2010年第7期638-639,共2页The Chinese Journal of Dermatovenereology

摘　　要：目的了解非梅毒螺旋体抗原血清学试验假阳性发生率及原因。方法对本院2007-2008年门诊及住院病人送检的血清标本进行快速血浆反应素(RPR)环状卡片试验和梅毒螺旋体颗粒凝集试验(TP-PA),对结果进行统计学分析。结果 2007-2008年合计检测了10546份血清标本,RPR假阳性率为0.21%(15/7002)。2007年(0.32%)与2008年(0.11%)的RPR假阳性率差异无统计学意义(P>0.05)。15例RPR假阳性血清标本中10例为有高危性行为的常规检查者,2例为孕妇,皮肌炎、尖锐湿疣和龟头破溃者各1例。结论 RPR假阳性有一定的发生率。建议RPR阳性者以TPPA等梅毒螺旋体抗原血清学试验进行确认。Objective To investigate the incidence and reasons of false-positive results in rapid plasma reagin （RPR） test. Methods The sera samples were tested with both RPR and Treponema pallidum particle assay （TPPA） from STD clinic clients, pre-admission and pre-operation patients in 2007 and 2008. Results A total of 10546 sera samples were tested. The total false positive RPR rate was 0.21% （15/7002）. No significant difference of the false positive rates was observed between 2007 and 2008 （ P 〉 0.05 ）. Among 15 sera samples with false positive RPR, ten from routine check-up had high-risk sex behaviors, two were pregnant women, and 1 was dermatomyositis, genital warts or glans ulcer pa- tients respectirely. Conclusions There is a certain false positive rate of RPR in clinical settings. It is suggested that patients with positive RPR be confirmed by specific syphilitic serologic test （ i. e. , TP- PA） while making diagnosis.

关 键 词：梅毒 快速血浆反应素试验 假阳性反应 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]