左西替利嗪、曲尼司特联合卡介苗素治疗慢性荨麻疹的临床观察  

Treatment on Chronic Urticaria with Levocetirizine and Tranilast Combined with BCG-PSN

作　　者：赵建华[1] 乔少华[1] 耿文军[1] 付吉星[1] 

机构地区：[1]山东省聊城市第二人民医院皮肤科,山东临清252601

出　　处：《中国皮肤性病学杂志》2010年第7期683-684,共2页The Chinese Journal of Dermatovenereology

摘　　要：目的观察左西替利嗪、曲尼司特联合免疫调节剂卡介苗素治疗慢性荨麻疹的疗效。方法将入选的患者随机分为3组:治疗组56例,予口服左西替利嗪5mg1次/d、曲尼司特0.1g3次/d联合卡介苗素2mL肌肉注射隔日1次治疗;对照A组45例予口服左西替利嗪和曲尼司特治疗,对照B组45例单纯口服左西替利嗪治疗,方法均同治疗组。三组均用药8周后评价疗效,停药1月后观察复发情况。结果治疗组有效率91.1%,明显优于两个对照组((75.6%,42.2%)(P均<0.05),差异有显著性;治疗组复发率(6/42例)低于两个对照组(9/26例,9/12例)。结论左西替利嗪、曲尼司特联合卡介苗素治疗慢性荨麻疹疗效好,复发率低。Objective To observe the efficacy of levocetirizine and tranilast combined with BCG-PSN on chronic urticaria. Methods Patients were randomly divided into treatment group（56 cases） , and two control groups （A and B, 45 cases in each group）. The treatment group orally took levocetirizine and tranilast combined with injection of BCG-PSN. The control group A orally took levocetirizine and tranilast. The control group B only took levoeetirizine. Eight weeks later, the evaluation of the efficacy was carried out and 4 weeks after drug withdrawal, recurrence was followed-up. Results After 8 weeks, effectiveness in the treatment group （91.1%） was significantly higher than that （75% and 42.2% ）in control groups （P 〈0.05）. The rate of relapse in control groups was significantly higher than that in the treatment group. Conclusion Levocetirizine and tranilast combined with BCG-PSN in the treatment of chronic urticaria has more satisfactory effect, and significantly low relapse.

关 键 词：左西替利嗪 曲尼司特 卡介苗素 慢性荨麻疹 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]