模式识别受体视黄酸诱导基因-Ⅰ样受体及信号通路研究进展  

Progress in the properties and signal transduction pathway of retinoic acid inducible gene Ⅰ like receptors

作　　者：陈聪[1] 姜北[1] 万瑛[2] 

机构地区：[1]第三军医大学学员旅二队,重庆400038 [2]第三军医大学全军免疫学研究所,重庆400038

出　　处：《免疫学杂志》2010年第7期636-638,共3页Immunological Journal

摘　　要：视黄酸诱导基因-I样受体(RLRs)是近年来发现的一类重要的模式识别受体。它能够通过识别病毒核酸如5’-三磷酸化的ssRNA和与长度相关的dsRNA,激活IPS-1、MITA等一系列信号分子,通过NF-kB和IRF-3/7两条通路引起I型干扰素等细胞因子的表达,进而发挥抗病毒效应。机体可通过多种调控因子对RLRs信号通路进行精细调控。RLRs信号通路对于理解机体抗病毒固有免疫应答具有重要价值。Recently retinoic acid inducible gene I like receptors（RLRs） were found as a kind of pattern recognition receptors,which can recognize 5＇-triphosphated single strands RNA or length-dependent double strands RNA from viruses.RLRs sequently activate a series of molecules,such as IPS-1 and MITA,and induce type I interferon production through NF-kB and IRF-3/7 pathways.The antiviral signal pathways are regulated precisely by a number of regulatory factors and believed to be of great value to understand antiviral innate immunity.

关 键 词：固有免疫 RLRs I型干扰素 

分 类 号：R392.12[医药卫生—免疫学]