B细胞在诱导免疫耐受中的作用机制  

The mechanism of B lymphocytes in inducing immune tolerance

作　　者：张国超 齐晖 李富荣 周汉新 

机构地区：[1]深圳市人民医院肝胆外科,518020 [2]深圳市人民医院临床医学研究中心,518020 [3]深圳市人民医院老年病研究所,518020

出　　处：《免疫学杂志》2010年第7期643-646,共4页Immunological Journal

基　　金：国家自然科学基金(30772042)

摘　　要：免疫耐受是机体对抗原的一种特殊免疫应答状态。在诱导耐受特别是在诱导外周T细胞耐受中,B细胞不仅可以分泌抗体及参与免疫调节,而且可以作为特异性的抗原提呈细胞起到重要作用。它可以活化T细胞导致免疫反应,也可以致T细胞耐受帮助诱导免疫耐受。认识B细胞如何诱导耐受可以为设计新的疗法调节自身免疫疾病和移植免疫中免疫耐受与免疫反应之间的平衡提供服务。Immune tolerance is a special immune response state against antigen in body. In the induction of tolerance especially in the induction of peripheral T-cell tolerance, B cells which can not only secrete antibodies and be able to participate in immune regulation but also can do as specific antigen-presenting cells play an important role. B cells can activate T-cell leading to immune response and still can tolerize T-cell inducing immune tolerance. Understand how B-cell induce B-cell tolerance can be in service to the design of new therapies regulating the balance between immune tolerance and immune response in autoimmune diseases and trans- plantation immunity.

关 键 词：B淋巴细胞 免疫耐受 抗原提呈 抑制因子 共刺激作用 

分 类 号：R392.12[医药卫生—免疫学]