病毒性心肌炎患者细胞免疫功能检测的临床意义  

Clinical significance of cellular immune function in patients with viral yocarditis

作　　者：文红英[1] 贾维坤[1] 刘利[1] 杨苓[1] 杨艳[1] 孙雪梅[1] 苟静[1] 张小燕[1] 魏蜀亮[1] 

机构地区：[1]川北医学院附属医院胸外科

出　　处：《细胞与分子免疫学杂志》2010年第7期685-686,共2页Chinese Journal of Cellular and Molecular Immunology

基　　金：四川省卫生厅课题资助(070304)

摘　　要：目的：探讨病毒性心肌炎患者细胞免疫功能检测的临床意义。方法：选择本院2008—01／2009—12收治的病毒性心肌炎患者75例作为实验组，以67例健康者作为对照组，分别在入院时和入院后24h内静脉采血，对治疗前后T细胞亚群、自然杀伤细胞（NK）活性及肿瘤坏死因子（TNF）进行检测和分析。结果：与入院时比较，入院24h后实验组外周血T淋巴细胞亚群CD3、CD4、CD8及CD4／CD8均有所提高，且CD3、CD4及CD4／CD8差异均具有统计学意义（P〈0．05），但仍略低于对照组，而差异不具有统计学意义；与此同时，与入院时比较，入院24h后实验组NK及TNF均有所提高，差异均具有统计学意义（P〈0．05），但仍略低于对照组，而差异不具有统计学意义。结论：更加深入地探讨病毒性心肌炎患者的免疫损伤机制将有助于更好地指导治疗，而且具有重要的临床意义。AIM： To probe into the clinical significance of cellular immune function in patients with viral myocarditis. METHODS： Choose our hospital in January 2008-December 2009 admitted during the 75 patients of viral myocarditis as the experimental group, 67 healthy patients served as control groups, respectively, and hospital admission within 24 h after the venous blood, before and after treatment T cell subsets, natural killer cells （NK） activity and tumor necrosis factor （TNF） were detected and analyzed. RESULTS： Compared with admission, 24h after admission test in pe- ripheral blood T lymphocyte subsets CD3, CD4, CD8 and CD4/CD8 were improved and CD3, CD4 and CD4/CD8 were statistically significant differences （ P 〈 0.05 ）, but still slightly lower in the control group, while the difference was not statistically significant. At the same time, compared with admission, 24 h after admission of natural killer cells in the experimental group （NK） and tumor necrosis factor were improved, the differences were statistically significant （ P 〈 0.05）, but still slightly lower than the control group, but the difference was not statistically significant. CONCLUSION： More in-depth study of viral myocarditis in patients with immune injury mechanism will help to better guide the treatment, and has important clinical significance.

关 键 词：病毒性心肌炎 T细胞亚群 自然杀伤细胞 

分 类 号：R392.12[医药卫生—免疫学]