脂肪来源间充质干细胞体外定向诱导分化血管细胞的研究进展  

Adipose Derived-Mesenchymal Stem Cells Differentiate into Vascular Cells in Vitro

作　　者：翟羽佳[1] 仉红刚[1] 

机构地区：[1]北京协和医学院中国医学科学院微循环研究所,北京100005

出　　处：《中国生物工程杂志》2010年第6期134-138,共5页China Biotechnology

基　　金：科技部社会公益专项(2005DIB1J086)资助项目

摘　　要：脂肪来源的间充质干细胞具有较强的体外增殖能力,因具有生物学特性稳定、来源充足、体外培养条件低等优势已引起各国学者的关注。脂肪间充质干细胞凭借其多向分化潜能,是人体干细胞库潜在的重要来源之一。目前,研究人员已成功地在体外将其诱导为内皮细胞,成骨细胞、成软骨细胞、脂肪前体细胞、平滑肌细胞,心肌细胞、神经样细胞等。就脂肪来源的间充质干细胞体外定向诱导分化血管细胞的研究进展作一综述。Adipose derived-mesenchymal stem cells（ad-MSCs）with high proliferative ability have been concerned about due to their steady bionomics,sufficient source and a common cultured condition in vitro.Their potentiality of multi-directional differentiation becomes the important origin of pool of human stem cells.Nowadays,ad-MSCs are successfully induced into endothelial cells,osteoblasts,chondroblasts,fat precursor cells,smooth muscle cells,myocardial cells,nerve-like cells and so on.A description of the basic concepts and currently research advance of the adipose derived-mesenchymal stem cells that can be differentiated to vascular wall cells in vitro was provided.

关 键 词：脂肪来源间充质干细胞 内皮细胞 平滑肌细胞 诱导分化 

分 类 号：Q819[生物学—生物工程]