静脉用蔗糖铁联合促红细胞生成素治疗肾性贫血患者的疗效观察  

Therapeutic effect of iron sucrose and human erythropoietin on renal anemia

作　　者：吕洁[1] 程立新[1] 

机构地区：[1]山东省聊城市第二人民医院肾内科,山东临清252600

出　　处：《中国医师进修杂志》2010年第19期15-17,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的 比较静脉用蔗糖铁与口服右旋糖酐铁治疗慢性肾衰竭患者肾性贫血的疗效与安全性.方法 将60例肾性贫血患者按照随机数字表法分为两组：静脉组静脉给予蔗糖铁100mg/次,每周2次;口服组给予右旋糖酐铁150 mg/d口服.观察治疗后4、8、12周血红蛋白（Hb）、红细胞压积（Hct）、铁蛋白（SF）和转铁蛋白饱和度（TSAT）等的变化,并观察治疗达标后不良反应发生情况.结果 治疗后静脉组Hb由治疗前（79.87±13.19）g/L上升为（106.11±12.38）g/L,口服组Hb由治疗前（85.41±11.49）g/L上升为（94.68±10.06）g/L,两组治疗前后比较差异均有统计学意义（P〈0.01）,且静脉组治疗后Hb水平明显高于口服组（P〈0.01）.静脉组治疗后血清SF、TSAT明显高于口服组（P〈0.01）.口服组发生不良反应5例（16.7%）,静脉组无不良反应发生.结论 静脉用蔗糖铁治疗肾性贫血的疗效及安全性明显优于口服右旋糖酐铁.Objective To determine the efficacy and safety of intravenous iron sucrose and oral iron dextran in renal anemia patients. Methods Sixty renal anemia patients were randomized into two groups：intravenous iron group（IV group, 100 mg iron sucrose twice a week） and oral iron group（oral group, 150 mg iron dextran every day）. The changes in hemoglobin （Hb）,hematocrit （Hct）,serum ferritin （SF）,and transferrin saturation （TSAT） were assessed on week 4,8, and 12 after treatment. The maintenance dosages of erythropoietin （EPO） after reaching treatment target and the adverse events were also observed. Results Hb increased after treatment in IV group [（79.87 ± 13.19） g/L to （106.11 ± 12.38） g/L] and oral group [（85.41 ± 11.49） g/L to （94.68 ± 10.06） g/L],and compared with that before treatment, there was significant difference in each group（P〈 0.01 ）. Also significant difference showed in Hb levels after treatment between two groups（P〈 0.01 ）. SF and TSAT levels were higher after treatment in IV group than those in oral group （P 〈 0.01 ）. The adverse event was lower in IV group （0） than that in oral group （16.7%,5/30）.Conclusions Oral iron dextran which has more adverse events and poor efficacy in curing anemia, can not correct anemia ideally. Meanwhile intravenous iron sucrose has positive effects on renal anemia with low adverse events, and it can be used as a long term iron supplementation in hemodialysis patients.

关 键 词：贫血 铁右旋糖酐复合物 红细胞生成素 蔗糖铁 

分 类 号：R692.5[医药卫生—泌尿科学]