干燥综合征动物模型建立及病理变化的初步探讨  

Primary research of development of a mouse model for non bacterial sialoadenitis

作　　者：俞创奇[1] 邱蔚六[1] 胡北平[1] 丁永敏[1] 

机构地区：[1]上海第二医科大学口腔医学院口腔颌面外科教研室

出　　处：《上海口腔医学》1999年第1期27-29,共3页Shanghai Journal of Stomatology

摘　　要：目的建立人类干燥综合征的动物模型，试图模拟其唾液腺的病理变化。方法运用同种鼠的颌下腺组织诱导类似于人类干燥综合症（ＳＳ）唾液腺表现的动物模型。结果不同品系鼠和不同抗原量组颌下腺淋巴细胞浸润程度不同，Ｃ５７品系鼠（注射抗原浓度５００μｇ／ｍｌ和７５０μｇ／ｍｌ组）浸润程度较明显；而饮水量与浸润淋巴细胞程度间无相关关系。结论初步建立了类似于人类ＳＳ表现的鼠动物模型。Objective To develope a mouse model for non bacterial sialoadenitis similar to SS.The model of organ specific to the submandibular gland of mouse has developed for this study. Methods Several of the mouse strains were used to the development of non bacterial sialoadenitis.The injection of syngeneic salivary gland tissue with CFA induced inflammation in submandibular gland in mice.Not all mice had a predictable response. Results C 57 mice(500μg/ml and 750μg/ml group)appear histologically to be more prove to develop sialoadenitis than other mouse trains.The pattern of the inflammation is similar to that demonstrated in human sialoadenitis. Conclusion An animal model of non bacterial sialoadenitis had been set up,the non bacterial sialoadenitis may be similar to the autoimmune process in human SS

关 键 词：干燥综合征 唾液腺 动物模型 病理学 

分 类 号：R442.8[医药卫生—诊断学]