冠状动脉性心脏病合并慢性牙周炎患者氧化低密度脂蛋白和纤维蛋白原的变化  

Change of Oxidized Low Density Lipoproteins and Fibrinogen in the Patients of Coronary Heart Disease with Chronic Periodontitis

作　　者：吴赟[1] 陈凌[1] 闫福华[2] 

机构地区：[1]福建医科大学附属第一医院口腔科,福建福州350005 [2]福建医科大学口腔医学院牙周科,福建福州350002

出　　处：《中华高血压杂志》2010年第6期570-574,共5页Chinese Journal of Hypertension

基　　金："十一五"国家科技支撑计划课题(2007BAI18B02);福建省科技重点资助项目(2007Y0016)

摘　　要：目的研究牙周炎症对冠状动脉性心脏病(冠心病)患者氧化低密度脂蛋白(ox-LDL)和纤维蛋白原(Fg)的影响。方法连续入选冠心病患者168例和非冠心病患者146例,通过问卷调查、牙周检查以及血液ox-LDL和Fg水平测定进行冠心病危险因素分析。结果冠心病组牙周炎发生率显著高于非冠心病组(75.6%比59.6%,P<0.05);冠心病合并慢性牙周炎患者ox-LDL和Fg水平显著高于单纯冠心病组[ox-LDL(543.8±187.8)比(448.8±76.0)μg/L;Fg(4.01±0.75)比(3.69±0.68)g/L,均P<0.05]。趋势检验结果显示,随着牙周炎程度的加重,患冠心病的风险也愈大(P<0.01);logistic回归分析显示,慢性牙周炎是冠心病的危险因素之一(P<0.05)。结论冠心病合并慢性牙周炎伴有更高水平的ox-LDL和Fg,慢性牙周炎可能是冠心病的危险因素之一。Objective To study the relationship between oxidized low density lipoproteins（ox-LDL） and fibrinogen（Fg） and chronic periodontitis in the patients of coronary heart disease（CHD）. Methods One hundren and sixty-eight patients with CHD and 146 cases of non-CHD were enrolled. Questionnaire and the examinations of patients＇ periodontal condition were performed in these patients. Plasma ox-LDL and Fg were determined. Results The prevalence of periodontitis in CHD was higher than that in non-CHD（75.6% vs 59.6%,P〈0.05）. Plasma ox-LDL and Fg in CHD with chronic periodontitis were higher than that in CHD alone [ox-LDL （543.8±187.8） vs （448.8±76.0）μg/L; Fg （4.01±0.75） vs （3.69±0.68）g/L; all P〈0.05]. The trend test showed that the longer the periods of periodontitis,the higher the risk of CHD. Logistic regression analysis showed that chronic periodontitis may be one of the independent risk factors of CHD（P〈0.05）. Conclusion CHD with chronic periodontitis may have a higher plasma level of ox-LDL and Fg,chronic periodontitis may be one of the independent risk factors of CHD.

关 键 词：慢性牙周炎 冠状动脉性心脏病 氧化低密度脂蛋白 纤维蛋白原 

分 类 号：R541.4[医药卫生—心血管疾病] R781.4[医药卫生—内科学]