米非司酮对孕7～9周人胎盘绒毛核因子-κB及环加氧酶的影响  

Effect of mifepristone on expression of nuclear factor-κB and cyclooxygenase in placental villi of women with 7-9 weeks gestation

作　　者：唐薇[1] 王自能[2] 黄健玲[1] 赵影庭[3] 

机构地区：[1]广东省中医院,广州510120 [2]暨南大学 [3]广东省佛山市妇幼保健院

出　　处：《中国计划生育学杂志》2010年第7期408-410,共3页Chinese Journal of Family Planning

摘　　要：目的:观察米非司酮对妊娠7～9周人胎盘绒毛中核因子(NF)-κB及环加氧酶COX表达的影响,探讨其药物流产机理。方法:采用免疫组化法检测NF-κB、COX-1及COX-2在米非司酮药物流产组与负压吸宫对照组(均孕7～9周各12例)胎盘绒毛中的表达。结果:NF-κB和COX-2在药物流产组滋养细胞中阳性表达均较对照组强(均P<0.01);COX-1在两组表达无明显差别(P>0.05)。结论:米非司酮用于人孕7～9周药物流产时,可通过激活核转录因子NF-κB使COX-2表达增多,进而可能通过影响前列腺素的合成等作用产生不利于妊娠的结果。Objective： To explore the mechanism of medical abortion with mifepristone by observing the effect of mifepristone on the expression of nuclear factor kappa B（NF-κB） and cyclooxygenase（COX） in the placental villi of women with 7-9 weeks gestation.Methods： A immunohistochemical analysis was used for evaluating the expressions of NF-κB,COX-1 and COX-2 in the placental villi of the women with 7-9 weeks gestation seeking for medical abortion（medical abortion group,n=12） and vacuum aspiration abortion（vacuum aspiration abortion group,n=12）.Results： In the medical abortion group,the expressions of NF-κB and COX-2 in trophoblast were significantly higher（P0.01）.The expression of COX-1 was no statistically significant difference between the two groups（P0.05）.Conclusion： When used for termination of early pregnancy in 7-9 weeks gestation,mifepristone can increase the expression of NF-κB and COX-2 in placental villi,resulting in the unfavorable effects on maintenance of pregnancy by increasing the prostaglandins synthesis.

关 键 词：米非司酮 胎盘绒毛 核因子-ΚB 环加氧酶 

分 类 号：R169.4[医药卫生—公共卫生与预防医学]