高血压病人微循环缺血区与血管内皮细胞损伤的关系  

A Study of the Relationship Between Ischemic Areas in Microcirculation And Injury of the Vascular Endothelial Cells in Hypertension

作　　者：郭渝成[1] 曾祖荫[1] 雷鸣[1] 张志高[1] 张碧霞[1] 陈敏[1] 

机构地区：[1]贵阳解放军44医院,550009

出　　处：《中国微循环》1999年第1期38-39,共2页Journal of Chinese Microcirculation

摘　　要：目的探讨高血压病人球结膜微循环缺血区与血管内皮细胞损伤间的关系。方法对６０例住院的Ⅱ期高血压病人，２０例正常人均进行球结膜微循环、血浆内皮细胞舒张因子（ＥＤＲＦ）、血浆内皮素（ＥＴ）、血浆循环内皮细胞（ＣＥＣ）检测。结果高血压病人微循环缺血区占５３．３％，正常人无一例出现，差异非常显著。高血压病人的ＥＤＲＦ明显降低，而ＥＴ和ＣＥＣ升高，与正常人相比均有显著性差异。结论高血压病人球结膜微循环缺血区的发生与血管内皮细胞损伤关系密切，二者相互作用，是导致高血压病发生和发展的重要原因之一。Objective To study the relationship between ischemic areas in the microcirculation and injury of the vascular endothelial cells in patients with stage Ⅱ essential hypertension. Methods Sixty patients with essential hypertension at stage Ⅱ and twenty normotensive persons were observed for the bulbar conjunctiva microcirculation. The circulating endothelial cells (CEC),plasma endothelin (ET),and plasma endothelium derived relaxing factor (EDRF) were measured. Results The incidence of ischemic area in patients with essential hypertension was 53.3% higher than that in normotensive persons (P<0.001).The CEC and plasma ET significantly increased (P<0.001) and the plasma EDRF markedly reduced in patients as compared with the normotensive group.It has been found that in patients with essential hyperension,ischemic areas in the microcirculation were closely related to dysfunction of the vascular endothelial cells. Conclusion They acted each other and became more and more serious,forming a vicious cycle that may play an important role in the pathogenesis and development of essential hypertension.

关 键 词：高血压 微循环缺血区 血管内皮细胞 细胞损伤 

分 类 号：R544.102[医药卫生—心血管疾病]