血液流变性对椎动脉血流动力学的影响  

The Role of Hemorrheology on Hemodynamic Change of Flow in Vertebral Artery

作　　者：李党生[1] 罗芳[1] 王敦德[1] 马建芳[1] 安一明 

机构地区：[1]解放军第476医院内三科,福州350002

出　　处：《中国微循环》1999年第1期42-44,共3页Journal of Chinese Microcirculation

摘　　要：目的探讨血液流变性对椎动脉血流动力学的影响。方法对２６例椎基底动脉供血不足患者的椎动脉ＣＤＦＩ参数与血液流变学指标作多元回归相关分析。结果Ｖｍ、Ａ、Ｑ、ＰＩ与部分流变学指标显著相关，其中Ｖｍ与 ηｂ（８０ｓ^(－１)），Ａ与ηｂ（２０ｓ^(－１)），Ｑ与ηｂ（８０ｓ^(－１)）分别是独立相关性（ｒ为－０.３３、－０．３３、－０．３１，Ｐ<０．０５）；ＰＩ则与Ｒηｂ（８０ｓ^(－１)）、ηｂ（８０ｓ^(－１)）、ηｐ、ＨＣＴ、Ｆｎ多项指标密切相关。Ｖｍ、Ｑ、ＰＩ均成功建立对１２项流变学指标的多元拟合模型。结论①血液流变性变化可改变椎动脉血流内部阻力和流速，从而影响其血流动力学状态；②Ｖｍ、ＰＩ等ＣＤＦＩ参数是综合反映椎动脉血流动力学和流变学两方面状态的较灵敏指标。Objective To investigate the effect of hemorrheologic change on hemodynamics in vertebral artery.Method The correlativity was assayed between the parameters of Color Doppler Flow Imaging(CDFI)in vertebral artery and hemorrheologic indices on 26 cases of patients with Vertebrobasilar insufficiency(VBI).Results Vin,A,Q,PI are correlated respectively with some hemorrheologic indices significantly, the closest were Vin vs ηb (80s^(-1)), Q vs ηb (80s^(-1)), A vs ηb (20s^(-1)) (=-0. 33, -0. 31,-0. 33 respectively, P<0. 05), in addition to PI vs R ηh (80s^(-1)), ηb(80s^(-1)), ηp, HCT and Fn. Meanwhile, multiple linear regression equation was successfully given on Vin,Q,PI respectively versus all of 12 hemorrheologic indices. Conclusions 1. Hemorrheologic change could alter the intrinsic resistance,speed and amount of flow in vertebral artery;2. Vm,PI are sensitive indices to reflect the change of both hemodynamics and hemorrheology in vertebral artery.

关 键 词：血液流变性 血流动力学 椎动脉 

分 类 号：R331.33[医药卫生—人体生理学]