转化生长因子β受体在牙胚发育过程中的表达和意义  

The expression and effect of TGF-β receptors in tooth development

作　　者：张莹[1] 张郁[1] 金岩[1] 

机构地区：[1]第四军医大学口腔医学院

出　　处：《牙体牙髓牙周病学杂志》1999年第1期11-13,共3页Chinese Journal of Conservative Dentistry

摘　　要：目的：探讨转化生长因子β受体在牙胚发育过程中的时空表达和对牙胚发育的影响。方法：建立小鼠牙胚发育模型，用免疫组织化学检测转化生长因子βⅠ型受体（ＴβＲ－Ⅰ）、Ⅱ型受体（ＴβＲ－Ⅱ）、Ⅲ型受体（ＴβＲ－Ⅲ）在牙胚发育中的表达。结果：转化生长因子βⅠ型受体、Ⅱ型受体在牙胚发育的蕾状期、帽状期、钟状期以及硬组织形成期均有表达，且随着成釉细胞和成牙本质细胞的逐渐成熟，表达增加，其中Ⅰ型受体比Ⅱ型受体表达量多，Ⅲ型受体仅在蕾状期的成釉器上皮和钟状期的内外釉上皮、牙囊有弱表达。结论：转化生长因子β受体在牙胚发育过程中的时空表达与成釉细胞、成牙本质细胞的分化密切相关。Aim: To observe the expression and effect of TGF-β receptors in tooth development. Methods: Establish model of mouse tooth development and examine TβR-Ⅰ,TβR-Ⅱand TβR-Ⅲ by immunohistochemical technique. Results: TβR-Ⅰwas found more intense staining than TβR-Ⅱin tooth bud、cap、 bell and hard tissue morphogenesis stages. TβR-Ⅲ was found only fewer positive cell in the epithelia of the tooth bud and inner and outer enamel epithelia and sac cell of the bell stage. Conclusion: Temporary and spatial expression of TGF-β receptors were closely related with differentiation of ameloblast and odontoblast.

关 键 词：牙胚发育 转化生长因子Β 受体 免疫组化 

分 类 号：R339.35[医药卫生—人体生理学] Q983.8[医药卫生—基础医学]