SOD1基因缺陷型小鼠耳蜗毛细胞和螺旋神经节及神经纤维的定量观察  

QUANTITATIVE ANALYSIS OF HAIR CELLS, SPIRAL GANGLION NEURONS AND NERVE FIBERS IN KNOCKOUT MICE LACKING SOD1 GENE

作　　者：丁大连[1] 蒋海燕 李明[1] 

机构地区：[1]佳木斯医学院附属医院

出　　处：《耳鼻喉学报》1999年第1期1-3,共3页

摘　　要：定量观察了出生后１３个月的先天缺失ＳＯＤ１基因小鼠的耳蜗毛细胞以及螺旋神经节和疆孔内的神经纤维，并与同龄野生型和出生后２个月的野生型小鼠进行了比较。发现毛细胞和螺旋神经节的缺损约为５０％，神经纤维的减少则超过５０％。The hair cells,spiral ganglions and nerve fibers in the cochlea were observed in 13 months old knockout mice lacking SOD1gene,which were compared with the same aged wild type mice and 2 months old wild type mice.It was found that the hair cells and gaglion neurons were missing 50%,and the nerve fibers were missing more than 50%in lacking SOD1 gene mice. This suggests that the serious damage in both hair cells and nerve system in the cochlea caused by lacking superoxide dismutase combined by copper and zinc.

关 键 词：毛细胞 神经纤维 螺旋神经节 SOD基因 耳蜗损伤 

分 类 号：R764.350.2[医药卫生—耳鼻咽喉科]