一种高精度SPR生物传感器的设计与实现  

Design and implementation of a SPR biosensor with high precision

作　　者：杨军[1] 王敏[1] 李圆怡[1] 战磊[1] 吴松[1] 胡宁[1] 

机构地区：[1]重庆大学生物工程学院,生物流变科学与技术教育部重点实验室,重庆400030

出　　处：《传感器与微系统》2010年第7期96-98,102,共4页Transducer and Microsystem Technologies

基　　金：国家"863"计划资助项目(2006AA04Z343);国家自然科学基金资助项目(30500120;30770569;30870661);重庆市科技攻关计划资助项目(CSTC2008AA5010)

摘　　要：表面等离体共振(SPR)技术被广泛应用于表面检测、生化免疫分析、药物筛选和环境监测等领域。介绍一种自行设计的基于Kretschmann结构的角度检测型SPR生物传感器。该装置采用角度连续扫描的方式,利用2个独立的步进电机分别驱动固定有棱镜和光电检测器件的大小转盘,可以进行单一样本的高精度分析。测试结果表明:该传感器具有很高的重复性与稳定性,噪声小、精度高。Surface plasmon resonance （SPR）technology has been widely used in many fields such as surface detection, biochemical immunoassays, drug screening, and environment monitoring, etc. A self-desinging anglescanning SPR biosensor based on Kretchmann configuration is introduced. In this device, continuous angle-scanning mode was adopted and two individual step motors were used to drive large and small plates where prism and photodetector were fixed, respectively. This device can analyze single sample with high precision. Experimental results validated that this sensor has good repeatability and stability, low noise, and high precision.

关 键 词：表面等离体共振 Kretschmann结构 转角式 生物传感器 

分 类 号：Q813.2[生物学—生物工程]