不同甲状腺功能绝经前女性血清饥饿素与全身骨量、肌肉量、体重的相关分析  

The correlation of serum ghrelin level with the total BMC,LM and body weight in premenopausal women with different thyroid functional status

作　　者：叶涛[1] 徐浩[1] 弓健[1] 

机构地区：[1]暨南大学附属第一医院核医学科,广东广州510630

出　　处：《中国病理生理杂志》2010年第7期1370-1374,共5页Chinese Journal of Pathophysiology

基　　金：广东省医学科研基金资助项目(No.A2008354)

摘　　要：目的:探讨不同甲状腺功能的绝经前女性血清饥饿素(ghrelin)水平与其身体成份骨量(BMC)、脂肪量(FM)、肌肉量(LM)的相互关系。方法:采用放射免疫分析法检测71例不同甲状腺功能的绝经前女性其中包括甲状腺机能亢进(甲亢)组33例、甲状腺机能减低(甲减)组18例、正常对照组20例的血清饥饿素水平,同时采用化学发光快速检测法检测其血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、灵敏促甲状腺激素(sTSH);并采用双能X线吸收法(DXA)测定其全身身体成份(骨量、脂肪量、肌肉量),同时记录体重(BW)。结果:(1)甲亢组血清饥饿素水平明显低于正常对照组(P<0.01)和甲减组(P<0.01),甲减组血清饥饿素水平与正常对照组之间无显著差别(P>0.05)。血清饥饿素与其FT3(r=-0.318,P<0.01)、FT4(r=-0.350,P<0.01)呈负相关,与sTSH(r=0.281,P<0.05)呈正相关。(2)血清饥饿素与全身骨量(r=0.284,P<0.05)、肌肉量(r=0.259,P<0.05)、体重(r=0.279,P<0.05)存在正相关;与脂肪量不存在相关(P>0.05)。结论:不同甲状腺功能的绝经前女性血清饥饿素可能影响其全身骨量、肌肉量、体重。AIM： To investigate the relationship between serum ghrelin level and body composition including bone mineral content （BMC）, fat mass（FM） ＆ lean mass（LM） in premenopausal women with different thyroid functional status. METHODS： We measured the serum ghrelin levels by radioimmunoassay （RIA）, the serum levels of free triiodo- thyronine （ FT3 ）, free thyroxine （ FT4 ） and sensitive thyroid - stimulating hormone （sTSH） by chemiluminescene immune assay. The total body composition including total BMC, FM and LM was measured by dual - energy X - ray absorptiometry （DXA） in 71 premenopausal women with different thyroid functional status （33 hyperthyroidism, 18 hypothyroidism and 20 normal subjects）. RESULTS： （1） The level of serum ghrelin in patients with hyperthyroidism was significantly lower than that in patients with hypothyroidism （P 〈 0. 01 ） and normal subjects （P 〈 0. 01 ）, but the serum ghrelin level in patients with hypothyroidism patients was similar to that in normal subjects （ P 〉 0. 05 ）. The serum ghrelin level was correlated negatively with FT3 （ r = - 0. 318, P 〈 0. 01 ） and FT4 （ r = - 0. 350, P 〈 0. 01 ）, simultaneously correlated positively with serum sTSH （ r =0. 281, P 〈0. 05）. （2） The serum ghrelin level in 71 premenopausal women with different thyroid functional status correlated positively with the total BMC （ r = 0. 284, P 〈 0. 05 ）, the total LM （ r = 0. 259, P 〈 0. 05 ）, body weight （ r = 0. 279, P 〈 0.05 ） but there was not correlation with total FM （P 〉 0. 05 ）. CONCLUSION ： The serum ghrelin level in the premenopausal women with different thyroid functional status may correlate with the total BMC, LM and body weight.

关 键 词：甲状腺功能亢进症 甲状腺功能减退症 GHRELIN 绝经前妇女 

分 类 号：R581[医药卫生—内分泌]