海藻酸钠/壳聚糖缓释微球的制备及性能  

Preparation and property of alginate/chitosan microspheres for controlled releasing

作　　者：王宏丽[1] 陈风雷[1] 陈涛[1] 胡雪梅[1] 李智[1] 辛莹[1] 

机构地区：[1]成都医学院药学院,四川成都610083

出　　处：《云南大学学报（自然科学版）》2010年第4期469-472,479,共5页Journal of Yunnan University(Natural Sciences Edition)

基　　金：成都医学院研究基金资助项目(NO.08Z030)

摘　　要：利用海藻酸钠(SA)聚阴离子及壳聚糖(CS)聚阳离子电解质的性质,以顺铂(DDP)为模型药,采用乳化交联法制备海藻酸钠-DDP缓释微球,根据静电吸附原理合成SA/DDP/CS复合载药微球.研究微球对药物分子的包载能力及释药特性.结果显示,制备的微球圆整,载药微球表面致密且分散性好,微球粒径在11.0～58.8μm之间,采用原子吸收分光光度计对载药微球的载药率、药物包封率和药物体外释放性质进行了测试和分析,结果表明载药微球缓释效果明显,减少了药物的投放量和投放次数,降低了毒副作用.Alginate （SA） and Chitosan （CS） were anion and cation polyelectrolyte,respectively. Using cis-Diamminedichloroplatinum （DDP） as the model drug, microspheres loaded with DDP were prepared by crosslinking-emulsion method.Electrostatic absorption technique was used to prepare DDP microspheres coated with CS.The drug loaded in SA/CS/DDP microspheres was observed by SEM,and the results indicated that these microspheres showed dense surface and excellent sphere-forming ability, and the sizes of microspheres are in the range of 11.0—58.8μm.In addition,the drug loading ratio and efficiency as well as drug releasing curves were also investigated in vitro,and the results showed that SA/DDP/CS microspheres displayed an excellent drug controlled releasing.

关 键 词：海藻酸钠 壳聚糖 顺铂 缓释 

分 类 号：O629.12[理学—有机化学]