电压门控性钙通道为靶点的镇痛药物研发进展  

Voltage-gated calcium channel as a target for new analgesic drugs

作　　者：王玉梅[1] 夏玉叶[1] 闵旸[1] 

机构地区：[1]上海医药工业研究院药理室,上海200437

出　　处：《世界临床药物》2010年第7期433-437,共5页World Clinical Drug

基　　金：国家"重大新药创制"科技重大专项资助(项目编号2009ZX09301-007)

摘　　要：对慢性非癌性疼痛的治疗目前仍然缺乏理想的镇痛药物,急需开发基于疼痛机制的靶向新型镇痛药物。电压门控性钙通道(VGCC)的改变是疼痛发生的重要分子基础,本文针对N型、T型及α2δ亚基VGCC为作用靶点的新型镇痛药物的研究进展作一综述。As the treatment o.f chronic noncancer pain lacks effective analgesics at present, it is necessary to develop new analgesics selectively acting on the specific targets. The changes of voltage-gated calcium channels are the important molecule base of pain. This review describes the advances in N-type, T-type and α2δ subgroup calcium channels to be the molecular targets for new analgesic drugs.

关 键 词：慢性疼痛 电压门控性钙通道 镇痛药物 

分 类 号：R971[医药卫生—药品] R741.05[医药卫生—药学]