吸入麻醉药预处理脑保护的研究进展  

Research Progress of Inhalational Anesthetics as Preconditioning Agents in Ischemic Brain

作　　者：袁华平[1] 孙德海[1] 

机构地区：[1]三峡大学第一临床医学院麻醉科,湖北宜昌443003

出　　处：《医学综述》2010年第14期2208-2210,共3页Medical Recapitulate

摘　　要：预处理在很多动物模型中被证明有抗脑缺血的作用,因此,通过预处理诱导脑缺血耐受可能成为临床上神经保护的有效方法。有很多种方法能通过预处理来诱导耐受,如缺血本身、药物、缺氧等。吸入麻醉药也能通过预处理对大脑产生保护作用。预处理产生脑保护的机制多且复杂,到现在还没有完全弄清,可能与Akt通道的激活、ATP敏感的钾离子通道、一氧化氮等有关。Preconditioning has been shown to protect the brain from cerebral ischemia in animal models.Therefore,one potential clinical neuroprotective strategy in humans may involve increasing the cerebral tolerance to ischemia by preconditioning.There are many methods to induce tolerance through preconditioning,such as ischemia itself,pharmacological treatment,hypoxia,and others.Inhalational anesthetic agents have also been shown to result in brain preconditioning.Mechanisms responsible for brain preconditioning are complex and unclear,which may involve Akt activation,ATP-sensitive potassium channels,and nitric oxide.

关 键 词：吸入麻醉药 脑保护 预处理 

分 类 号：R971.2[医药卫生—药品]