动态观察处于灰区的乙肝表面抗原的变化趋势  

Trend of hepatitis B surface antigen in grey area

作　　者：张汉奎[1] 苗霞[1] 何结冰[1] 陈桂山[1] 蔡常辉[1] 张秀明[1] 

机构地区：[1]广东中山大学附属中山医院检验医学中心,广东中山528403

出　　处：《海南医学院学报》2010年第7期937-938,共2页Journal of Hainan Medical University

基　　金：海南医学院科研基金资助学报项目(0020100266)~~

摘　　要：目的:对乙肝表面抗原(HBsAg)检测中处于灰区范围内的患者进行动态观察,分析其发展趋势,提高检测准确度。方法:采用酶联免疫吸附试验(ELISA)方法,选取HBsAg初检结果在灰区范围的117例,并在1年后对117例复检标本进行HBsAg复检实验。结果:117例标本1年后的复检试验中,24例ELISA结果≥1.2,阳性率为20.5%;29例ELISA结果≤0.8,阴性率为24.8%;诊断明确标本数53例,占总标本的45.3%;其余64例复检标本ELISA结果仍处于0.8～1.2之间,其占总标本的54.7%。结论:检测HBsAg实验结果处于灰区范围的被检者进行动态观察,特别在一定时间间隔内重新取样检查,可以明显提高检测的准确度及HBsAg检验的应用价值,有的甚至还可以发现产生灰区的原因。Objective：To consecutively observe patients with gray interval results of HBsAg Assay,analyze the trend,and to raise the detecting accuracy.Methods：A total of 117 patients with gray interval results of HBsAg Assay were selected by ELISA assay and were tested again one year later.Results：Out of 117 samples,there were 24 samples with ELISA results higher than 1.2（positive rate as 20.5%）,and 29 samples lower than 0.8（negative rate as 24.8%）.A total of 53 samples were confirmed accounting for 45.3%,and the rest 64 samples had the ELISA results between 0.8 and 1.2,accounting for 54.7%,Conclusions：Dynamic monitoring samples with gray interval results of HBsAg Assay,especially repeated detection one year later,can markedly boost accuracy.

关 键 词：乙肝表面抗原 酶联免疫吸附试验 灰区范围 复检 

分 类 号：R512.62[医药卫生—内科学]