凤尾蕨属6种药用植物抗肿瘤有效部位筛选  

Screening of the Antitumor Active Fractions from 6 Medicinal Plants of Pteris L.

作　　者：龚先玲[1,2] 苟占平[1,2] 梁念慈[2] 刘义[2] 李立[2] 

机构地区：[1]广东医学院.药学院,广东东莞523808 [2]广东医学院广东天然药物研究开发重点实验室,广东湛江524023

出　　处：《时珍国医国药》2010年第7期1599-1601,共3页Lishizhen Medicine and Materia Medica Research

基　　金：广东省自然科学基金(No.8152402301000019);广东省科技计划项目(No.2009B030801336);广东省东莞市高等院校科研机构科技计划项目(No.2008108101050)

摘　　要：目的对凤尾蕨属6种药用植物抗肿瘤有效部位进行筛选。方法采用MTT法对凤尾蕨属6种药用植物不同溶剂萃取物进行体外抗肿瘤活性测试。结果半边旗的醋酸乙酯萃取物、正丁醇萃取物;刺齿半边旗的石油醚萃取物、醋酸乙酯萃取物、正丁醇萃取物;井栏边草的醋酸乙酯萃取物、正丁醇萃取物;剑叶凤尾蕨的醋酸乙酯萃取物;线羽凤尾蕨的正丁醇萃取物对人肺癌细胞A549增殖均有明显的抑制作用。结论上述凤尾蕨属几种药用植物的萃取物具有较好的体外抗肿瘤活性,是其抗肿瘤作用的有效部位。Objective To screen the active fraction with antitumor effect from 6 medicinal plants of Pteris L..Methods The samples of the 6 plants were extracted with ethanol at first,and then the ethanol extracts were separated with petroleum ether,ethyl acetate,n-Butyl alcohol in turn to get three fractions.Then the antitumor effect of the extracts were tested with MTT method.Results Ethyl acetate and n-BuOH extracts of Pteris semipinnta L.,petroleum ether,ethyl acetate and n-BuOH extracts of P.dispar Kze.,ethyl acetate and n-BuOH extracts of P.multifida Poir.,ethyl acetate extract of P.ensiformis Burm.,and n-BuOH extract of P.linearis L.were shown to have significant inhibitory effect against human lung cancer cell A549.Conclusion The extracts of the plants from Pteris are proved to be the antitumor active fractions in vitro.

关 键 词：凤尾蕨属 抗肿瘤作用 有效部位 

分 类 号：R285.5[医药卫生—中药学]