赤雹果多糖对免疫抑制小鼠免疫功能的影响  

Effects of Polysaccharide from the Fruit of Thladiantha dubia Bunge on the Immunefunctions of Immunosuppressed Mice

作　　者：赵波[1] 张玉玲[1] 佟继铭[1] 

机构地区：[1]承德医学院中药研究所,河北承德067000

出　　处：《时珍国医国药》2010年第7期1627-1629,共3页Lishizhen Medicine and Materia Medica Research

基　　金：河北省自然科学基金(No.C200600863);河北省教育厅资助项目(No.2005225)

摘　　要：目的观察赤雹果多糖对免疫抑制模型小鼠免疫功能的影响。方法采用环磷酰胺(CY)造模法制作小鼠免疫抑制模型,观察赤雹果多糖对实验动物免疫器官重量指数、碳粒廓清能力、迟发型变态反应(DTH)、溶血素(IgM)含量的影响。结果赤雹果多糖400,200mg·kg-1剂量组能显著提高小鼠免疫脏器指数、单核巨噬细胞的吞噬功能及小鼠迟发型超敏反应,促进溶血素的生成。结论赤雹果多糖有显著提高免疫抑制小鼠免疫功能的作用。Objective To observe the effects of polysaccharide from the fruit of Thladiantha dubia Bunge on the immune functions of immunosuppressed mice.Methods Immunosuppressed mouse model was established by intraperitoneal injection with cyclophosphamide followed by daily intragastric administration of polysaccharide from the fruit of Thladiantha dubia Bunge.After the treatment,the mice were examined for immune organ weight index,carbon particle clearance capability of macrophage,delayed type hypersensitivity,serum IgM level following exposure to sheep erythrocytes.Results Treatment of the immunosuppressed mice with polysaccharide from the fruit of Thladiantha dubia Bunge at the daily dose of 400 and 200 mg·kg-1 significantly increased the weight of the immune organs,carbon particle clearance capability of macrophage,delayed type hypersensitivity,serum IgM level against erythrocytes.Conclusion The polysaccharide from the fruit of Thladiantha dubia Bunge can enhance the immune functions of immun...更多osuppressed mice induced by cyclophosphamide. 还原

关 键 词：赤雹果 多糖 免疫功能 环磷酰胺 

分 类 号：R285.5[医药卫生—中药学]