128例急性脑梗塞患者血清b-FGF变化与血淤证的相关性研究  

Association between Changes of b-FGF Content and Blood Stasis Syndrome in Patients with Acute Cerebral Infarction

作　　者：李林森[1,2] 田金洲[1] 蔡艺灵[3] 时晶[2] 

机构地区：[1]中央民族大学中国少数民族传统医学研究院,北京100081 [2]北京中医药大学东直门医院,北京100700 [3]中国人民解放军第306医院,北京100101

出　　处：《时珍国医国药》2010年第7期1743-1744,共2页Lishizhen Medicine and Materia Medica Research

基　　金：国家"973"重点基础研究发展计划资助项目(No.2003CB517104)

摘　　要：目的探讨急性脑梗塞患者血清b-FGF变化与血淤证的相关性。方法对来源于中国人民解放军第306医院的128例脑梗塞患者进行中医证候要素评分及血清b-FGF测定。结果血清b-FGF比较,血淤证组与非血瘀证组均无显著差异(P>0.05)。脑梗塞血淤证与血清b-FGF无明显相关(P>0.05)。结论急性脑梗塞血淤证与b-FGF无明显相关,该研究对于从细胞层面研究血瘀证的生物学基础有着重要意义。Objective To investigate the blood stasis syndrome（BSS）defined by traditional Chinese medicine in cerebral infarction and its correlations with b-FGF.Methods All subjects comprised 128 patients with acute ischemis stroke,which were based on Diagnostic Criteria for Cerebral Vascular Diseases in 2005.Diagnosis for syndromes defined by traditional Chinese medicine were made according to Diagnostic Criteria for Stroke in 1994.Patients were examined with ELISA for MMP-9 and TIMP-1 in blood serum.Results The content of b-FGF had no difference between patients with BSS and CI and those patients without BSS had CI（P 〉0.05）.There had no significant correlation between b-FGF and BSS in patients with cerebral infarction（P〉0.05）.Conclusion There is significant correlationship between b-FGF and BSS in patients with cerebral infarction.This preliminary study is of importance for study in biological basis of BSS by cell levels.

关 键 词：脑梗塞 B-FGF 血淤证 

分 类 号：R446.112[医药卫生—诊断学] R54[医药卫生—临床医学]