β-细胞腺苷三磷酸-敏感性钾通道基因E23K多态性与2型糖尿病关系的Meta分析  

Association of Polymorphisms in KCNJ11 Gene with Type 2 Diabetes:A Meta-analysis

作　　者：田芸[1] 李亚[2] 

机构地区：[1]成都医学院校医院,四川省成都市610083 [2]成都医学院生物医学系

出　　处：《中国全科医学》2010年第20期2233-2235,共3页Chinese General Practice

基　　金：成都医学院创新实验项目(2009154)

摘　　要：目的采用Meta分析系统评价β-细胞腺苷三磷酸-敏感性钾通道(KCNJ11)基因E23K多态性与2型糖尿病(T2DM)的关系。方法用"KCNJ11、E23K、type 2 diabetes、r5219、polymorphism"等关键词检索PubMed、CNKI和VIP数据库中发表于1996—2009年的文献。选择所有有关KCNJ11基因E23K多态性与T2DM相关性的随机病例对照研究,并用Revman 4.2软件进行统计分析。结果共纳入19篇符合条件的文献,累计T2DM病例11806例,对照13 556例。数据合并结果显示,病例组K等位基因频率显著高于对照组,OR=1.18,95%CI(1.11,1.26)(P<0.01);病例组与对照组的KK/(EE+EK)基因型频率间差异有统计学意义,OR=1.37,95%CI(1.20,1.56)(P<0.01)。结论 KCNJ11基因E23K多态性与T2DM易患性相关,其KK基因型可能是T2DM发病的危险因子。Objective To assess by meta- analysis the association of E23K polymorphism in the potassium inwardly - rectifying channel, subfamilyl, member 11 （ KCNJ11 ） gene with type 2 diabetes mellitus （T2DM）. Methods All case - control studies involved in the relationship between E23K polymorphisms of KCNJ11 gene and T2DM were retrieved from PubMed, CNKI and VIP databases （1996 -2009. 12）. All statistical analyses were performed with RevMan4. 2 software. Results Nineteen eligible articles were selected in this study, including 11806 T2DM cases and 13556 healthy controls. The combined data revealed that K allele frequency of study group was significantly higher than that of control, OR = 1.18, 95% CI （ 1.11 , 1. 26） （P 〈 0. 01 ）. There was significant difference in KK/ （ EE ＋ EK） gene frequency between 2 groups, OR = 1.37, 95% CI （1.20, 1.56） （P 〈0. 01 ）. Conclusion KCNJll gone E23K polymorphism is correlated with T2DM susceptibility, and KK gene types may be a risk factor of T2DM.

关 键 词：糖尿病 2型 META分析 KCNJ11基因 多态性 

分 类 号：R587.1[医药卫生—内分泌]