6ThZ(E)OK/6ThZ(E)O方案治疗2HRZ(E)S/4HR治疗失败菌阳肺结核的疗效观察  

Observation on the therapeutic effects of 6ThZ(E) OK/6ThZ(E) O in the treatment of patients who had failed in the 2HRZ(E) S/4HR treatment for their sputum positive tuberculosis

作　　者：黄汉平[1] 张丽[1] 周霞[1] 邹鹏[1] 周金海[1] 

机构地区：[1]武汉市医疗救治中心,湖北武汉430023

出　　处：《临床肺科杂志》2010年第8期1119-1120,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨6ThZ(E)OK/6ThZ(E)O方案治疗2HRZ(E)S/4HR治疗失败菌阳肺结核的临床疗效。方法选择菌2HRZ(E)S/4HR治疗失败阳肺结核84例,随机分为观察组38例和对照组46例,化疗方案分别采取6ThZ(E)OK/6ThZ(E)O和3HRZES/9HRE。观察两组治疗第1、2、6个月末和疗程末痰菌转阴、病灶吸收、空洞变化情况及不良反应。结果观察组疗程末痰菌阴转率、肺内病灶吸收好转率及空洞闭合好转率均优于对照组(P<0.05),两组均无严重不良反应发生。结论应用6ThZ(E)OK/6ThZ(E)O方案治疗菌阳2HRZ(E)S/4HR治疗失败肺结核疗效更有优势,值得临床推广。Objective To observe the clinical therapeutic effects of 6ThZ（E） OK/6ThZ（E） O in the treatment of patients who had failed in the 2HRZ（E） S/4HR treatment for the sputum positive tuberculosis.Methods A total of 84 cases chosen in a randomized way were divided into study group（n = 38） and control group（n = 46）.The treatment measures were 6ThZ（E） OK/6ThZ（E） O and 3HRZES/9HRE for the study and the control group,respectively.Results When the treatment was completed,the negative conversion rate,focus absorptivity and cavity closing rate in the study group were better than that in the control group（P〈 0.05）.No obvious severe adverse effects were found in the two groups.Conclusion The therapeutic effects of 6ThZ（E） OK/6ThZ（E） O is perfect for the re-treatment of sputum positive tuberculosis.It is valuable in clinical application.

关 键 词：肺结核 治疗失败 疗效 

分 类 号：R521[医药卫生—内科学]