蒺藜总皂苷对AD大鼠GSK-3β的影响  

Effect of Gross Saponin from Tribulus Terrestris L on Alzheimer's Disease Rats

作　　者：彭胜国[1] 甘云波[2] 

机构地区：[1]武汉大学基础医学院,湖北武汉430071 [2]咸宁学院基础医学院

出　　处：《咸宁学院学报（医学版）》2010年第3期189-191,共3页Journal of Xianning Univarsity(medical Sciences)

摘　　要：目的探讨蒺藜总皂苷对AD大鼠GSK-3β的影响。方法采用AlCl3灌胃制作AD大鼠模型,Morris水迷宫检测大鼠空间记忆能力,免疫印迹检测GSK-3β蛋白水平。结果蒺藜总皂苷明显缩短大鼠寻找平台的时间,降低GSK-3β蛋白水平。结论蒺藜总皂苷能有效改善因AlCl3所致的大鼠空间记忆障碍,其机制可能与抑制GSK-3β蛋白过度激活有关。Objective To investigate the effect of gross saponin from Tribulus terrestris L（GSTT） on Alzheimer＇s disease（AD） rats.Method The AD model was established by AlCl3.Spatial memory retention and the expression of GSK-3β protein were detected by Morris and Western blot,respectively.Results It was shown that the escape latency was increased significantly after AlCl3 injection in Morris maze,and GSTT could markedly shorten AlCl3-induced the increase of escape latency,decrease the expression of GSK-3β protein.Conclusion These results suggest that GSTT can effectively prevent the rats from AlCl3-induced spatial memory deficits by inhibiting GSK-3β overactivation.

关 键 词：蒺藜总皂苷 阿尔茨海默病 空间记忆 GSK-3Β 

分 类 号：R965.7[医药卫生—药理学]