急性一氧化碳中毒患者核磁共振成像和质子磁共振波谱研究  

Research of magnetic resonance image and H1-magnetic resonance spectroscopy in patients with carbon monoxide poisoning

作　　者：徐芳[1] 张禹[2] 高晓晴[1] 黄海滨[1] 张嵘[1] 汪青松[1] 

机构地区：[1]解放军第105医院神经内科,合肥230031 [2]解放军第105医院放射科,合肥230031

出　　处：《中国临床保健杂志》2010年第3期233-235,共3页Chinese Journal of Clinical Healthcare

基　　金：全军医药卫生科研基金课题(06H009);南京军区医药卫生科研基金课题(06MA51)

摘　　要：目的研究急性一氧化碳中毒(COP)患者核磁共振成像(MRI)和质子磁共振波谱(H1-MRS)的改变,评价两者在COP预后的应用价值。方法研究对象(COP组30例,正常对照组20例)同时进行常规MRI和H1-MRS检查,测量H1-MRS各感兴趣区化合物的峰下面积及相对值。结果 COP患者常规MRI可表现正常,也可表现异常。COP患者的HI-MRS均有不同程度的异常,与正常对照组相比:COP组NAA/Cr比显著降低,Cho/Cr比显著升高(P<0.05);而一氧化碳中毒迟发性脑病(DNS)患者NAA/Cr比降低更明显,Cho/Cr比升高更显著,并有Lip峰出现。结论 Hl-MRS比常规MRI较早检测出COP患者脑部病灶的代谢异常,为COP的预后评估提供有益的信息。Objective To investigate the change of magnetic resonance image （MRI） and H1-magnetic resonance spectroscopy （MRS） in patients with carbon monoxide poisoning （COP） and evaluate the value of MRS or MRI in prediction of COP.Methods MRS and MRI were performed in COP group （30 patients） and control group （20 healthy volunteers）.The area under each peak of MRS and comparative value were obtained in each volume of interest.Results The outcome of MRI could be normal or abnormal in patients with COP.The outcome of MRS all was abnormal in patients with COP.Compared to control group,value of Cho/Cr in COP group significantly increased （P〈0.05）,while NAA/Cr significantly decreased （P〈0.05）.Compared to COP group,value of Cho/Cr in DNS group was much more high （P〈0.05） and value of NAA/Cr was much more lower （P〈0.05）.The peak of lip was detected in DNS patients.Conclusion Our data indicated that MRS might detect earlier abnormality of brain metabolism in COP patients than MRI.In some extent,the change of MRS may have some value in diagnosing DNS early.

关 键 词：一氧化碳中毒 缺氧 脑 磁共振成像 磁共振波谱学 

分 类 号：R595.1[医药卫生—内科学]