开郁清胃颗粒对代谢综合征患者胰岛功能的影响  

Treatment of Kaiyuqingwei Granules for Pancreatic Islet Function of Metabolic Syndrome

作　　者：陈良[1] 仝小林[1] 赵天宇[2] 董柳[1] 赵昱[3] 

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]卫生部中日友好医院,北京100029 [3]民航总医院,北京100123

出　　处：《中国中医药信息杂志》2010年第7期7-9,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：首都医学发展基金(ZRYH-BJ200304Ⅲ-24)

摘　　要：目的初步探讨开郁清胃颗粒对代谢综合征患者胰岛功能的影响。方法将90例代谢综合征患者随机分为观察组和对照组,每组45例。观察组应用开郁清胃颗粒治疗,对照组应用马来酸罗格列酮(文迪雅)治疗。疗程12周。观察2组患者空腹和餐后30、60、120、180min血糖和胰岛素、糖化血红蛋白(HbA1c),计算胰岛β细胞功能指数及早期胰岛素分泌指数。结果 2组患者各个时间点血糖以及HbA1c均显著降低(P<0.01),空腹及糖负荷后0.5、1、2、3h的胰岛素水平显著降低(P<0.01);患者经胰岛素抵抗调整后的早期胰岛素分泌指数明显升高。2组比较差异无统计学意义(P>0.05)。结论开郁清胃颗粒可改善代谢综合征患者的胰岛β细胞功能。Objective To investigate the effect of Kaiyuqingwei Granules （KG） for improving pancreatic islet function of metabolic syndrome （MS）. Methods Ninety patients were divided into KG group and rosiglitazone group, 45 patients in each group. Two groups were treated with corresponding medicine and observed for 12 weeks. FBG, PG 30, 60, 120, 180 min, insulin secretion, HbA1c, HBCI, MBCI, EISI and REISI were observed. Result Glucose of every time point and HbA1c were reduced （P〈0.01）. Insulin secretion of fasting and glucose loading 0.5, 1, 2, 3 h were all reduced. Insulin secretion index was increased. Conclusion KG can improve pancreatic islet function of MS patients.

关 键 词：代谢综合征 开郁清胃颗粒 胰岛功能 

分 类 号：R259.89[医药卫生—中西医结合]