双膦酸盐类药物中4种有机溶剂的顶空毛细管气相色谱法测定  

Determination of Residual Organic Solvents in Bisphosphonates by Headspace Capillary Gas Chromatography

作　　者：雷利利[1] 刘丰华[1] 蒋晔[1] 

机构地区：[1]河北医科大学药学院,河北石家庄050017

出　　处：《中国医药工业杂志》2010年第7期533-535,共3页Chinese Journal of Pharmaceuticals

基　　金：河北省自然基金资助项目(C2009001069)

摘　　要：以离子液体([Emim][BF4])为顶空溶剂,建立了顶空毛细管气相色谱法测定双膦酸盐类药物中甲醇、乙醇、丙酮和氯苯的残留量。采用DB-624色谱柱,FID检测器,顶空平衡温度120℃,平衡时间20min。4种有机溶剂的回收率为97.1%～100.3%,RSD均小于3.0%。检测限分别为0.15、0.06、0.06和0.007μg/ml。An headspace capillary gas chromatography method was established for the determination of methanol,ethanol,acetone and chlorobenzene in bisphosphonates with ionic liquid as matrix medium.A DB-624 capillary column was used with temperature program and FID detector,at injection temperature 120 ℃ and equilibrium time 20 min.The recoveries were 97.1%-100.3%,with the RSDs less than 3.0%.Their detection limits were 0.15,0.06,0.06 and 0.007 μg/ml,respectively.

关 键 词：双膦酸盐类药物 有机溶剂残留 离子液体 顶空毛细管气相色谱 测定 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.71[化学工程—制药化工]