坦索罗辛和普鲁苯辛对输尿管下段结石体外冲击波碎石术后辅助排石的疗效比较  

Comparison of tamsulosin and propantheline bromide in the management of lower ureteral stones after extracorporeal shock wave lithotripsy

作　　者：颜自兵 

机构地区：[1]广东省中山市港口医院,528447

出　　处：《中国医学创新》2010年第17期22-23,共2页Medical Innovation of China

摘　　要：目的分析比较坦索罗辛和普鲁苯辛在输尿管下段结石体外冲击波碎石术后辅助排石的疗效。方法 150例输尿管下段结石患者随机分为3组,每组50例,结石直径0.4～1.0 cm。对照组未给予输尿管平滑肌松弛剂;普鲁苯辛组给予普鲁苯辛15 mg,3次/d;坦索罗辛组给予坦索罗辛0.2 mg,1次/d。每例患者治疗观察期不超过2周。结果 2周内结石排出者对照组为42例(84%),普鲁苯辛组为46例(92%),坦索罗辛组为47例(94%)。各组比较排石率无显著差异(P>0.05)。各组平均排石时间分别为(5.5±4.0)d、(5.1±2.8)d、(4.5±2.6)d,普鲁苯辛、坦索罗辛组较对照组时间短,差异有统计学意义(P<0.01),坦索罗辛组较普鲁苯辛组短,差异有统计学意义(P<0.01)。结论在输尿管下段结石体外冲击波碎石术后,坦索罗辛和普鲁苯辛在辅助排石方面是安全、有效的,能缩短结石排出时间,坦索罗辛作用优于普鲁苯辛。Objective To compare the effectiveness of tamsulosin and propantheline bromide in the management of lower ureteral stones after ESWL. Methods A total of 150 patients with stones（0.4 - 1.0 cm in diameter） located in the lower ureter were enrolled in the study and randomly divided into 3 groups（50 cases in each group）. Group 1 served as controls; group 2 received propantheline bromide （ 15 mg,3 times daily） ;and group 3 received tamsulosin（0.2 mg once daily）. All patients were observed for 2 weeks. Results Daring 2 weeks, expulsion of stones was observed in 42 patients in group 1 （ 84% ） ,46 in group 2 （92%） and 47 in group 3 （ 94% ）, which was not statistically significant （ P 〉 0.05 ）. Average expulsion time for groups 1 to 3 was （ 5.5 ± 4.0 ）, （ 5.1 ± 2.8 ） and （4.5 ± 2.6 ） days, respectively. The difference of which in group 1 with respect to group 2 and 3 was significant（ P 〈 0.01 ） ; the difference of which in group 2 with respect to group 3 was sig- nificant（P 〈0.01 ）. Conclusion It is demonstrated that tamsulosin and Drooantheliue bromide are safe and effective in adjunctive expulsive treatments of lower urcteral stones after ESWL. They both can reduce the stone expulsion time, particularly tamsulosin.

关 键 词：输尿管结石 坦索罗辛 普鲁苯辛 

分 类 号：R693.4[医药卫生—泌尿科学]