糖调节受损患者代谢综合征因子的特征性改变  

Clinical Analysis of the Characteristics Distribution of the Metabolic Syndrome Factors in IGR

作　　者：李茜[1] 张融[1] 李兴贵[1] 顾峻菱[1] 潘雪[1] 

机构地区：[1]重庆市第五人民医院,400062

出　　处：《中国医药指南》2010年第20期195-197,共3页Guide of China Medicine

摘　　要：目的评价正常糖耐量(NGT)、糖调节受损(IGR)、2型糖尿病(T2DM)个体代谢综合征各因子的特征性分布。方法对入选139例个体作口服75g葡萄糖耐量试验(OGTT)、糖化血红蛋白及血脂谱检查,测量身高、体质量、血压、腹围,并进行统计学分析。结果①IGR组和T2DM组的BMI、腹围、SBP、DBP显著高于NGT组(P<0.05,P<0.01);②IGR组和T2DM组TC、TG、LDL-C、空腹血糖、2h血糖、糖化血红蛋白显著高于NGT组(P<0.05,P<0.01),T2DM组空腹血糖、2h血糖、糖化血红蛋白显著高于IGR组(P<0.01);③IGR组和T2DM组高血压病、腹型肥胖、血脂异常的患病率显著高于NGT组(P<0.01)。结论糖耐量受损患者已存在与代谢综合征有关的代谢组分异常,对于糖尿病前期的治疗应重视对多重危险因素的综合控制。Objective To study the characteristics distribution of the metabolic syndrome factors in NGT,IGR and T2DM.Methods Totally 139 individuals were included in the present study.The subjects were divided into normal group,impaired glucose regulation（IGR） group and diabetes mellitus（DM） group based on the body mass index（BMI） ,blood pressure,glucose concentration,and lipid profile.The clinical characteristics of subjects were compared between different groups.Results①The BMI,abdominal circumference,SBP,DBP of IGR group and T2DM group were significantly greater than the NGT group（P〈0.05,P〈0.01） ;②The TC,TG,LDL-C,fasting blood sugar,2h blood sugar,glycosylated hemoglobin of the IGR group and T2DM group were significantly greater than the NGT group（P〈0.05,P〈0.01） ,and the fasting blood sugar,2h blood sugar,glycosylated hemoglobin of T2DM group were significantly greater than the IGR group（P〈0.01） ;③The prevalence rate of hypertension,abdominal obesity,dyslipidemia of IGR group and T2DM group were significantly greater than the NGT group（P〈0.01） .Conclusion The IGR group have occurred the abnormal metabolic composition which is correlated with metabolic syndrome.

关 键 词：糖调节受损 代谢综合征 

分 类 号：R587.3[医药卫生—内分泌]