Runx3和Ki-67蛋白在皮肤恶性黑色素瘤中的表达  

Expression of Runx3 and Ki-67 in Cutaneous Malignant Melanoma

作　　者：曹俊华[1] 陈旻静[1] 陈建华[1] 

机构地区：[1]郑州大学第一附属医院整形外科,河南郑州450052

出　　处：《中国美容医学》2010年第7期1013-1014,共2页Chinese Journal of Aesthetic Medicine

摘　　要：目的:检测Runx3和Ki-67蛋白在皮肤恶性黑色素瘤(CMM)中的表达水平,以探讨Runx3和Ki-67在CMM发生、发展过程中的作用。方法:采用免疫组织化学法研究Runx3和Ki-67蛋白在皮肤恶性黑色素瘤、皮肤交界痣及正常皮肤中的表达。结果:Runx3蛋白在CMM中阳性表达率为23.68%,与皮肤交界痣(85.00%)和正常皮肤(90.00%)相比,差异具有统计学意义(P<0.05);Ki-67蛋白在CMM中阳性表达率为78.95%,与皮肤交界痣(25.00%)和正常皮肤(25.00%)相比差异具有统计学意义(P<0.05)。结论:皮肤恶性黑色素瘤的产生可能与Runx3蛋白的表达降低及Ki-67蛋白的表达升高有关。Objective To detect the expression of Runx3 and Ki-67 in Cutaneous Malignant Melanoma（CMM）,in order to explore Runx3＇ and Ki-67＇ effection during the generation and development of CMM.Methods Immunohistochemistry technique was perfomed to evaluate the alterations of the Runx3 and Ki-67 protein in CMM,Junction Nevus and normal skin tissues.Results The expression rate of Runx3 protein in the CMM,Junction Nevus and normal skin is 23.68%,85.00%,90.00%.There was a statical significance between the CMM and Junction Nevus or normal skin （P〈0.05）;The expression rate of Ki-67 protein in the CMM,Junction Nevus and normal skin is 78.95%,25.00%,25.00%.There was a statical significance between the CMM and Junction Nevus or normal skin （P〈0.05）.Conclusion The occurrence and development of CMM may be related to the low-expression rate of Runx3 protein and the high-expression rate of Ki-67 protein.

关 键 词：RUNX3 KI-67 皮肤恶性黑色素瘤 

分 类 号：Q813.1[生物学—生物工程]