紫癜颗粒对ITP模型小鼠骨髓细胞因子IL-3 TPO的影响  

The Effect of Purpura Particle on the Content of IL-3,TPO in Bone Marrow Cells of ITP Model Mice

作　　者：乔铁[1] 范颖[1] 林庶茹[2] 马骥[1] 

机构地区：[1]辽宁中医药大学方剂学科,辽宁沈阳110032 [2]辽宁中医药大学中医分子生物实验室,辽宁沈阳110032

出　　处：《辽宁中医杂志》2010年第7期1385-1387,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：教育部博士点基金项目(20050162002);辽宁省科技厅项目(2050367)

摘　　要：目的:通过观察ITP模型小鼠骨髓细胞白介素-3(IL-3)、血小板生成素(TPO)含量的变化,探讨IL-3、TPO含量变化与免疫性血小板减少性紫癜(ITP)发病之间的内在联系。方法:采用酶联免疫方法检测ITP模型小鼠骨髓细胞IL-3、TPO含量变化。结果:模型组小鼠骨髓细胞IL-3明显降低、TPO含量明显升高,均有统计学意义(P<0.05)。结论:调节巨核细胞的正性作用因IL-3与正性作用因子TPO参与了ITP的发病过程并发挥重要作用,紫癜颗粒通过调控骨髓细胞IL-3、TPO的含量变化而达到有效治疗ITP的目的。Objective：To discuss the relationship of the content of Interleukin-3（IL-3）,Thrombopoietin（TPO） and onset of Idiopathic Thrombocytopenic Purpura（ITP）,by examining the content change of IL-3,TPO in bone marrow cells of ITP model mice.Methods：Enzyme-linked immunosorbent assay（ELISA） was applied to measure the content of IL-3,TPO in bone marrow cells of ITP model mice.Results：In bone marrow cells of the model group,the content of IL-3 decreased,the content of TPO increased,both with significance in statistics（P〈0.05）.Conclusion：Positive acting factors that regulate megakaryocyte：IL-3 and TPO participate in the onset of ITP and play an important role.Purpura Particle can treat ITP in the effective way by regulating the content of IL-3 and TPO.

关 键 词：紫癜颗粒 免疫性血小板减少性紫癜模型 细胞白介素-3 血小板生成素 

分 类 号：R285.5[医药卫生—中药学]