IDO与胆囊癌的免疫耐受  

Indoleamine 2,3-dioxygenase and immune tolerance in the gallbladder carcinoma

作　　者：张鹏[1] 焦兴元[1] 石景森[2] 

机构地区：[1]广州医学院第二附属医院肝胆外科,广州510260 [2]西安交通大学医学院第一附属医院普外科,西安710061

出　　处：《国际外科学杂志》2010年第7期476-479,共4页International Journal of Surgery

基　　金：国家自然科学基金资助项目（No.30840096）

摘　　要：吲哚胺2,3双加氧酶（IDO）是色氨酸沿犬尿酸途径分解代谢的限速酶,其高表达是导致肿瘤免疫耐受的原因之一,直接影响树突状细胞（DC）疫苗的肿瘤治疗效果.脂多糖和细胞凶子等物质可调节IDO的表达.IDO通过3种机制参与肿瘤局部免疫耐受.对IDO的这种免疫调节机制的深入研究将在胆囊癌等肿瘤治疗方面具有重大意义.Indoleamine 2,3-dioxygenase（IDO）is the rate-limiting enzyme in the catabolism of trypto-phan along the kynurenine pathway.Over expression of IDO is one of the reasons which are responsible for immune tolerance of tumor.IDO also affects the effects of the vaccine of the dendritic cell in the tumor therapy.Lipopolysaccharide（LPS）,cytokines and so on can regulate the expression of IDO via different regulating mechanisms.IDO participates in the local immune tolerance of tumor by three kinds of mechanisms.Further research on this immunological regulatory mechanism will be significant for tumor immunotherapy.

关 键 词：吲哚胺2 3双加氧酶 免疫耐受 树突状细胞 胆囊癌 色氨酸 

分 类 号：R392[医药卫生—免疫学] R735.8[医药卫生—基础医学]