HIV抗体不确定及HIV抗体检测非特异反应的人群回顾性研究  

Characterization of HIV Antibody Indeterminate Status and Impact Factors on HIV Tests

作　　者：杨晓莉[1] 李敬云[2] 郝钦芳[1] 杨京民 张丽萍[1] 王莉[1] 马雪平[1] 王贝晗[1] 李军 宋宣[5] 卢光祥 王海燕[1] 

机构地区：[1]武警总医院检验科,北京100039 [2]军事医学科学院微生物流行病研究所,北京100071 [3]武警北京一总队医院检验科,北京100027 [4]武警北京二总队医院检验科,北京100037 [5]武警新疆总队医院检验科,新疆乌鲁木齐830000 [6]武警贵州总队医院检验科,贵州贵阳550005

出　　处：《中华医院感染学杂志》2010年第13期1844-1846,共3页Chinese Journal of Nosocomiology

基　　金：卫生部艾滋病防治应用性研究项目资助(WA-2006-07)

摘　　要：目的阐明我国HIV抗体不确定结果的发生频率、在预示HIV感染方面的价值。方法对122 165例临床患者、160 747名新兵体检人群、654例吸毒人群、2950例生化或免疫异常人群,合计286 516例的HIV抗体检测数据进行回顾性分析。结果临床患者(0.027%)、新兵体检人群(0.009%)、吸毒人群(0.0%)、生化或免疫异常人群(0.10%)等;4类人群的HIV不确定发生率显著不同(P<0.05);肝移植、骨折和皮肤科就诊患者HIV抗体不确定发生率分别为0.014%、0.13%、1.32%,显著高于体检人群0.024%(P<0.05);自身免疫性疾病患者中类风险因子(RF)水平高的HIV不确定是抗核抗体(ANA)阳性组的20倍(2%vs0.1%),但差异无统计学意义;肝、肾、肺部疾病患者HIV抗体非特异反应较高。结论 HIV不确定发生率在不同人群中显著不同,高危人群中的非特异反应及不确定结果的发生率最低;疾病因素与HIV不确定的发生相关。OBJECTIVE To clarify the frequency and value of HIV antibody indeterminate status and,to study the impact factors.METHODS A total of 286,516 HIV antibody samples collected from clinical patients,police recruits,drug users and persons with abnormality in biochemistry or immunology were tested and retrospectively analyzed.RESULTS The HIV indeterminate status varied significantly among different populations,（P〈0.05）： for clinical patients,police recruits,drug users and abnormal persons,the rate of HIV antibody-indeterminate status was 0.027%,0.009%,0.0% and 0.1%;and it correlated with patients 11 kinds of diseases,such as the liver transplantation,fracture and skin diseases,and with abnormal biochemistry,or immunology persons.CONCLUSION The HIV indeterminate status is significantly different in different populations.The incidence of non-differential reaction and indeterminate status in high-risk groups are the lowest,the caused factors of diseases are correlated with the indeterminate status.

关 键 词：HIV抗体 HIV不确定 临床患者 

分 类 号：R512.91[医药卫生—内科学]