无锡地区尖锐湿疣患者皮损中人乳头状瘤病毒的检测和分型  

Identification and Assessment of Multiple Human Papillomavirus Types in Condyloma Acuminatum Lesions from Patients with Genital Warts in Wuxi Area

作　　者：毕鸣晔[1] 黄海峰[1] 施和建[1] 张滨[2] 

机构地区：[1]无锡市人民医院皮肤科,江苏无锡214023 [2]无锡市人民医院中心实验室,江苏无锡214023

出　　处：《中华医院感染学杂志》2010年第14期2022-2024,共3页Chinese Journal of Nosocomiology

摘　　要：目的分析无锡地区尖锐湿疣患者人乳头状瘤病毒的基因类型和分布特点。方法利用人乳头状瘤病毒基因芯片对148例尖锐湿疣患者进行23种人乳头状瘤病毒亚型检测。结果 148例尖锐湿疣患者中,HPV-DNA检测阳性率高达95.27%,共检测出15种人乳头状瘤病毒亚型,其中低危型人乳头状瘤病毒6、11和43型出现频率分别为44.59%、51.35%和2.70%,高危型人乳头状瘤病毒16、18、31、33、45、51、52、56、58、59、66、68型出现的频率分别为13.51%、2.03%、1.35%、1.35%、0.68%、0.68%、3.38%、2.70%、1.35%、0.68%、4.05%、0.68%;单一感染占68.24%,高危型/低危型人乳头状瘤病毒交叉感染占27.03%。结论无锡地区尖锐湿疣以单一型别及低危型人乳头状瘤病毒11、6型感染为主,高危型人乳头状瘤病毒感染以人乳头状瘤病毒16型为主。OBJECTIVE To identify and assess the multiple human papillomavirus types in condyloma acuminatum（CA） lesions from patients with genital warts in Wuxi area.METHODS There were 23 genotypes of HPV in 148 patients with CA determined by gene-chips.RESULTS The positive rate of HPV was 95.27% in 148 patients with CA,15 HPV genotypes were detected and the incidence of low risk HPV genotypes 6,11 and 43 was 44.59%,51.35% and 2.70%;while the incidence of high risk HPV genotypes 16,18,31,33,45,51,52,56,58,59,66 and 68 was 13.51%,2.03%,1.35%,1.35%,0.68%,0.68%,3.38%,2.70%,1.35%,0.68%,4.05% and 0.68%,respectively.The positive rate of single type infection with HPV was 68.24%,the high-/low-risk HPV mixed infection was 27.03%.The predominant type from other healthy patients was HPV11.CONCLUSIONS HPV11 and HPV6 are the major pathogens in CA in Wuxi area and the main cause of the high-risk HPV infection is HPV16.

关 键 词：尖锐湿疣 人乳头状瘤病毒 基因芯片 

分 类 号：R373[医药卫生—病原生物学]