高血糖伴肥胖患者血清C反应蛋白与胰岛素抵抗的相关性研究  

Correlation of serum C-reactive protein levels with insulin resistance in obese hyperglycemic case

作　　者：栾健[1] 张杰涛[1] 董砚虎[2] 王瑶[1] 邴兆伟[1] 

机构地区：[1]青岛市市立医院,山东青岛266011 [2]青岛市内分泌糖尿病医院暨研究所,山东青岛225006

出　　处：《中国实用内科杂志》2010年第7期640-641,共2页Chinese Journal of Practical Internal Medicine

摘　　要：目的探讨肥胖高血糖患者的血清C反应蛋白(CRP)和胰岛素抵抗的关系。方法测定研究对象的空腹血糖(FPG)、2h血糖(2hPG)、空腹胰岛素(INS)、身高和体重,计算体重指数(BMI)和胰岛素抵抗指数(Homa-IR)。依据BMI和PG,分为正常对照组30例、单纯肥胖组30例、肥胖并糖调节异常(IGR)组30例、肥胖并T2DM组30例。应用快速免疫消浊比浊法测定血清CRP水平。结果 (1)与正常对照组相比,其余各组CRP和Homa-IR升高,均有统计学差异(均P<0.001);(2)与单纯肥胖组相比,肥胖并IGR组和肥胖并T2DM组CRP和Homa-IR均升高,有统计学差异(分别为P<0.05,P<0.01);与肥胖并IGR组相比,肥胖并T2DM组CRP水平升高,有统计学差异(P<0.001)。(3)相关分析显示Homa-IR与血清CRP(r=0.38,P<0.01)和BMI(r=0.26,P<0.05)呈显著正相关。结论肥胖人群存在低度慢性炎症,且与糖代谢密切相关。Objective To study the relationship between serum C-reactive protein （CRP） levels and insulin resistance （IR） in patients with hyperglycemia and obesity. Methods Fasting plasma glucose （FPG） ,2h plasma glucose （2hPG）, fasting insulin （INS）, patient height and weight were measured. Body mass index （BMI） and Homa insulin resistance index （Homa-IR） were calculated. Based on BMI and PG, the participants were divided into 4 groups ： normal control group （ 30 cases）, simple obesity group （30 cases）, impaired glucose regulation （IGR） obesity group （30 cases） and type 2 diabetic obese group （30 cases）. Serum C-reactive protein levels were measured with immunoturbimetric assay. Results （ 1 ） CRP and the Homa-IR in other groups were significantly increased comparing with normal control group, with statistical difference observed （P 〈0. 001 for all other groups）. （2） Comparing with simple obesity group, the CRP and Homa-IR in IGR obesity group and type 2 diabetic obesity group were increased, with statistical difference noted （P 〈 0. 05 and P 〈 0. 01 respectively）. Comparing with IGR obesity group, the CRP in type 2 diabetic obesity group was significantly increased, with statistical difference observed （P 〈 0. 001 ）. （3）Correlation analysis showed that Homa-IR was positively correlated with serum CRP （ r = 0. 38,P 〈 0. 01 ） and BMI （ r = 0. 26, P 〈 0. 05 ）. Conclusion Chronic low grade inflammation may exist in the obese crowd, which is closely associated with glycometabolism.

关 键 词：肥胖 高血糖 C反应蛋白 胰岛素抵抗 

分 类 号：R5[医药卫生—内科学]