麻葛全蝎汤对急性脑梗死患者t-PA、PAI的影响及临床评价  

Effect and Clinical Estimation of Mage Quanxie Tang on t-PA、PAI in Patients with Acute Cerebral Infarction

作　　者：白雪[1] 王明杰[1] 杨思进[1] 罗钢[1] 陈冲[1] 

机构地区：[1]泸州医学院附属中医医院心脑内科

出　　处：《中国中医药现代远程教育》2010年第13期40-42,共3页Chinese Medicine Modern Distance Education of China

摘　　要：目的探讨＂麻葛全蝎汤＂对急性脑梗死患者组织型纤溶酶原激活物（t-PA）以及组织型纤溶酶原激活物抑制物（PAI）活性的影响及临床评价。方法将60例急性脑梗病人,随机分为观察组30例,对照组30例。观察组采用基础治疗加麻葛全蝎汤100ml,tid,对照组采用基础治疗,2周为1个疗程。观察对比总有效率;t-PA以及PAI活性的变化及中国脑卒中临床神经功能缺损评分（CSS）、美国国立卫生研究院卒中量表（NIHSS）评分。结果经治疗后,观察组和对照组总有效率分别为93.33%、76.67%,两组有着显著差异（P〈0.01）;两组t-PA及PAI检测指标都有不同程度改善,差异均有统计学意义（P〈0.05）,其中以麻葛全蝎汤组PAI水平改善更为明显,与对照组相比差异有统计学意义（P〈0.05）;两组CSS、NIHSS评分均有不同程度改善,观察组CSS评分改善较对照组更为显著（P〈0.05）;结论以＂祛风活血法＂组方的中药复方制剂＂麻葛全蝎汤＂治疗急性脑梗死疗效确切,能升高血浆t-PA、降低PAI水平,调节血浆纤溶系统功能,有效改善神经功能缺损评分,且疗效优于单独西药治疗。Objective To discuss the effect and clinical estimation of Mage Quanxie Tang on t-PA, PAl in patients with acute cerebral infarction. Methods sixty patients with acute cerebral infarction cases were randomly divided into observation group （n=30） and control group （n=30） .Cases in observation group were treated with basic treatment and Mage Quanxie Tang 100ml,tid, cases in control group were treated with basic treatment, two weeks a course of treatment. The main observation and comparison index included total effective rate, activity changes of t-PA and PAI, score of Neural dysfunction of two groups were evaluated by Chinese Clinical Stroke Scale （ CSS ）, National Institutes of Health Stroke Scale （NIHSS） . Result After the treatment, the total effective rate was 93.33% in observation group and 76.67% in control group （P〈0.01）; the index of t-PA and PAI in two groups improved by different degrees （P〈0.05） ,and the index of PAI in Mage Quanxie Tang group significantly improved, it showed statistical significance compared with the control group （P〈0.05）; the scores of CSS, NIHSS in two groups improved by different degrees, scores of observation group improved significantly than that of control group （P〈0.05） .Conclusion Mage Quanxie Tang made by ＂eliminating wind and activating the circulation of blood＂ has definite effect on treating acute cerebral infarction, it can increase t-PA, decrease PAI in serum, regulate the function of Fibrinolysis system, improve the score of Neural dysfunction.

关 键 词：急性缺血性中风 麻葛全蝎汤 祛风活血法 

分 类 号：R277.7[医药卫生—中医学]