七叶皂苷钠在术后早期炎性肠梗阻治疗中的应用及其可能作用机制探讨  

作　　者：邓锋[1] 黄涛[1] 

机构地区：[1]天津西青医院普外科,300380

出　　处：《当代医学》2010年第19期156-157,共2页Contemporary Medicine

摘　　要：目的探讨七叶皂苷钠在术后早期炎性肠梗阻治疗中的临床应用特点及其作用机制。方法回顾性分析我院2007年3月～2010年4月收治的47例术后早期炎性肠梗阻的病例资料,资料分两组:治疗组(27例)和对照组(20例)。两组均采用禁食、胃肠减压、生长抑素、肠外营养等支持基础疗法,治疗组另给予七叶皂苷钠。结果治疗组经非手术治疗全部临床治愈(100%),无再手术病例,平均治愈时间10.2d(7～18d);对照组经非手术治疗17例(85%)临床治愈,3例中转开腹手术,平均治愈时间14.6d(9～23d)。结论非手术保守治疗对术后早期炎性肠梗阻效果满意,应用七叶皂苷钠能够促进肠梗阻的再通,提高治愈率,减少治愈时间,减轻患者长期置管痛苦。七叶皂苷钠的作用机制可能是减轻肠壁水肿,减少肠道炎性渗出,促进肠道蠕动。Objective To explore the clinical application characteristics and mechanism of aescin in the treatment of early postoperative inflammatory ileus. Methods The clinical data of 47cases of the early postoperative inflammatory small bowel obstruction,our hospital admitted in Mar.2007 to April 2010 were analyzed retrospectively. The patients were divided into two groups： treatment group （27cases） and control group （20 cases）. All patients were fasting,gastrointestinal decompression,somatostatin,parenteral nutrition support basic therapy, Treatment group plus aescine sodium. Results Treatment group were all clinical cure in non-surgical treatment（100%）,no reoperation. The average healing time was 10.2d（7～18d） 17 cases were clinical cured in control group（85%）,3 cases were converted to open surgery. The average healing time was 14.6d（9～23d）. Conclusion Non-surgical conservative treatment of early postoperative inflammatory ileus is satisfactory. Sodium aescinate can promote recanalization of intestinal obstruction, improve the cure rate, reduce healing time and the suffering of long-term catheter. Sodium aescinate mechanisms may be reduce the intestinal wall edema, reduce the enteric inflammatory exudate, and promote intestinal peristalsis.

关 键 词：七叶皂苷钠 术后早期炎性肠梗阻 临床应用 

分 类 号：R656.7[医药卫生—外科学]